Leibniz Institute of Polymer Research Dresden, Dresden, Germany.
Small. 2012 Dec 7;8(23):3579-83. doi: 10.1002/smll.201201397. Epub 2012 Aug 22.
Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.
智能纳米载体是基于 RAFT 和 ATRP 技术的双官能异引发剂，以及两种聚合物类型的介孔硅纳米粒子的双官能化而构建的。通过电动测量验证了 PDEAEMA 作为守门聚合物的 pH 依赖性行为，并使用阿霉素作为药物展示了其控制释放行为。
