通过结合表面引发原子转移自由基聚合（ATRP）和可逆加成-断裂链转移聚合（RAFT）来合成杂化聚合物功能化纳米载体。
Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization.
机构信息
Leibniz Institute of Polymer Research Dresden, Dresden, Germany.
出版信息
Small. 2012 Dec 7;8(23):3579-83. doi: 10.1002/smll.201201397. Epub 2012 Aug 22.
PMID:22911545
Abstract
Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.
摘要
智能纳米载体是基于 RAFT 和 ATRP 技术的双官能异引发剂，以及两种聚合物类型的介孔硅纳米粒子的双官能化而构建的。通过电动测量验证了 PDEAEMA 作为守门聚合物的 pH 依赖性行为，并使用阿霉素作为药物展示了其控制释放行为。
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