Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Eur J Cancer Prev. 2013 Mar;22(2):169-80. doi: 10.1097/CEJ.0b013e32835849ca.
The aim of this study was to evaluate the conflicting reports from the Environmental Protection Agency and the Scientific Advisory Panel (Panel) on the carcinogenicity of atrazine in order to determine whether the results from epidemiologic studies support a causal relationship between atrazine and any specific cancer. We reviewed the Environmental Protection Agency and Panel reports in the context of all the epidemiologic studies on the specific cancers of interest. A weight-of-evidence approach leads to the conclusion that there is no causal association between atrazine and cancer and that occasional positive results can be attributed to bias or chance. Atrazine appears to be a good candidate for a category of herbicides with a probable absence of cancer risk. Atrazine should be treated for regulatory and public health purposes as an agent unlikely to pose a cancer risk to humans.
本研究旨在评估美国环保署和科学顾问小组（Panel）关于莠去津致癌性的相互矛盾的报告，以确定流行病学研究的结果是否支持莠去津与任何特定癌症之间存在因果关系。我们在所有关于特定癌症的流行病学研究的背景下审查了美国环保署和 Panel 的报告。证据权重的方法得出的结论是，莠去津与癌症之间没有因果关系，偶尔出现的阳性结果可以归因于偏倚或偶然性。莠去津似乎是一种没有癌症风险的除草剂类别中的良好候选物。出于监管和公共卫生的目的，莠去津应被视为一种不太可能对人类造成癌症风险的药剂。
