Department of Rheumatology, Oslo University Hospital, Norway. klerang@ous-hf
Lupus. 2012 Oct;21(12):1362-9. doi: 10.1177/0961203312458168. Epub 2012 Aug 22.
Our aim was to identify all patients with systemic lupus erythematosus (SLE) within the city of Oslo from 1999-2008 and to estimate the incidence and prevalence of SLE according to age, sex and ethnicity. Adults (16 years and over) with SLE were identified from five different sources. Only patients fulfilling four or more of the updated 1997 American College of Rheumatology (ACR) criteria were included. The incidence was stable during the nine year study period, with a mean annual incidence rate of 3.0 per 100,000 at risk (95% confidence interval (CI) 2.4-3.5). Females exhibited a bimodal pattern in age specific incidence with the first peak at 16-29 years of age and the second at 50-59 years of age. The overall prevalence was 51.8 per 100,000 population (95% CI 45.2-58.4), with 91.0 (95% CI 78.8-103.1) for females and 10.7 (95% CI 6.4-15.0) for males. The prevalence proportions for European descendants were similar to those for Asians but statistically significant lower than those for individuals adopted from non-European countries. The findings indicate a higher prevalence in Norwegians compared to Caucasians in Denmark and England. The higher prevalence of SLE in foreign adopted individuals warrants further examination.
我们的目的是确定从 1999 年到 2008 年期间在奥斯陆市的所有系统性红斑狼疮（SLE）患者，并根据年龄、性别和种族来估计 SLE 的发病率和患病率。从五个不同的来源中确定了成年人（16 岁及以上）患有 SLE。只有符合最新的 1997 年美国风湿病学会（ACR）标准的四项或以上标准的患者才被纳入研究。在九年的研究期间，发病率保持稳定，风险人群中每年的发病率平均为 3.0/10 万（95%置信区间为 2.4-3.5）。女性在特定年龄的发病率呈双峰模式，第一个高峰在 16-29 岁，第二个高峰在 50-59 岁。总体患病率为每 10 万人 51.8 例（95%置信区间为 45.2-58.4），其中女性为 91.0（95%置信区间为 78.8-103.1），男性为 10.7（95%置信区间为 6.4-15.0）。欧洲后裔的患病率比例与亚洲人相似，但统计学上明显低于非欧洲国家收养的人。研究结果表明，与丹麦和英国的白种人相比，挪威人 SLE 的患病率更高。外国收养者中 SLE 患病率较高值得进一步研究。
