Izmirly Peter M, Parton Hilary, Wang Lu, McCune W Joseph, Lim S Sam, Drenkard Cristina, Ferucci Elizabeth D, Dall'Era Maria, Gordon Caroline, Helmick Charles G, Somers Emily C
New York University School of Medicine, New York, New York.
New York City Department of Health and Mental Hygiene, Long Island City, New York.
Arthritis Rheumatol. 2021 Jun;73(6):991-996. doi: 10.1002/art.41632. Epub 2021 Apr 23.
Epidemiologic data on systemic lupus erythematosus (SLE) are limited, particularly for racial/ethnic subpopulations in the US. This meta-analysis leveraged data from the Centers for Disease Control and Prevention (CDC) National Lupus Registry network of population-based SLE registries to estimate the overall prevalence of SLE in the US.
The CDC National Lupus Registry network includes 4 registries from unique states and a fifth registry from the Indian Health Service. All registries defined cases of SLE according to the American College of Rheumatology (ACR) 1997 revised classification criteria for SLE. Case findings spanned either 2002-2004 or 2007-2009. Given the heterogeneity across sites, a random-effects model was used to calculate the pooled prevalence of SLE. An estimate of the number of SLE cases in the US was generated by applying sex/race-stratified estimates to the 2018 US Census population.
In total, 5,417 cases were identified as fulfilling the ACR SLE classification criteria. The pooled prevalence of SLE from the 4 state-specific registries was 72.8 per 100,000 person-years (95% confidence interval [95% CI] 65.3-81.0). The prevalence estimate was 9 times higher among females than among males (128.7 versus 14.6 per 100,000), and highest among Black females (230.9 per 100,000), followed by Hispanic females (120.7 per 100,000), White females (84.7 per 100,000), and Asian/Pacific Islander females (84.4 per 100,000). Among males, the prevalence of SLE was highest in Black males (26.7 per 100,000), followed by Hispanic males (18.0 per 100,000), Asian/Pacific Islander males (11.2 per 100,000), and White males (8.9 per 100,000). The American Indian/Alaska Native population had the highest race-specific SLE estimates, both among females (270.6 per 100,000) and among males (53.8 per 100,000). In 2018, an estimated 204,295 individuals (95% CI 160,902-261,725) in the US fulfilled the ACR classification criteria for SLE.
A coordinated network of population-based SLE registries provides more accurate estimates of the prevalence of SLE and the numbers of individuals affected with SLE in the US in 2018.
关于系统性红斑狼疮（SLE）的流行病学数据有限，尤其是在美国的种族/族裔亚人群中。这项荟萃分析利用了疾病控制与预防中心（CDC）基于人群的SLE登记系统的国家狼疮登记网络数据，以估计美国SLE的总体患病率。
CDC国家狼疮登记网络包括来自不同州的4个登记处和印第安卫生服务部的第5个登记处。所有登记处均根据美国风湿病学会（ACR）1997年修订的SLE分类标准定义SLE病例。病例发现时间跨度为2002 - 2004年或2007 - 2009年。鉴于各研究地点之间的异质性，采用随机效应模型计算SLE的合并患病率。通过将按性别/种族分层的估计值应用于2018年美国人口普查数据，得出美国SLE病例数的估计值。
总共确定了5417例符合ACR SLE分类标准的病例。4个特定州登记处的SLE合并患病率为每10万人年72.8例（95%置信区间[95%CI] 65.3 - 81.0）。女性的患病率估计值比男性高9倍（每10万人中分别为128.7例和14.6例），在黑人女性中最高（每10万人中230.9例），其次是西班牙裔女性（每10万人中120.7例）、白人女性（每10万人中84.7例）和亚太岛民女性（每10万人中84.4例）。在男性中，SLE患病率在黑人男性中最高（每10万人中26.7例），其次是西班牙裔男性（每10万人中18.0例）、亚太岛民男性（每10万人中11.2例）和白人男性（每10万人中8.9例）。美国印第安/阿拉斯加原住民人群的种族特异性SLE估计值最高，无论是女性（每10万人中270.6例）还是男性（每10万人中53.8例）。2018年，估计美国有204,295人（95%CI 160,902 - 261,725）符合ACR SLE分类标准。
一个基于人群的SLE登记协调网络能更准确地估计2018年美国SLE的患病率以及受SLE影响的个体数量。
