纽约县（曼哈顿）系统性红斑狼疮的发病率和患病率：曼哈顿狼疮监测计划。
The Incidence and Prevalence of Systemic Lupus Erythematosus in New York County (Manhattan), New York: The Manhattan Lupus Surveillance Program.
机构信息
New York University School of Medicine, New York, New York.
Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.
出版信息
Arthritis Rheumatol. 2017 Oct;69(10):2006-2017. doi: 10.1002/art.40192. Epub 2017 Sep 10.
OBJECTIVE
The Manhattan Lupus Surveillance Program (MLSP) is a population-based registry designed to determine the prevalence of systemic lupus erythematosus (SLE) in 2007 and the incidence from 2007 to 2009 among residents of New York County (Manhattan), New York, and to characterize cases by race/ethnicity, including Asians and Hispanics, for whom data are lacking.
METHODS
We identified possible SLE cases from hospital records, rheumatologist records, and administrative databases. Cases were defined according to the American College of Rheumatology (ACR) classification criteria, the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria, or the treating rheumatologist's diagnosis. Rates among Manhattan residents were age-standardized, and capture-recapture analyses were conducted to assess case underascertainment.
RESULTS
By the ACR definition, the age-standardized prevalence and incidence rates of SLE were 62.2 and 4.6 per 100,000 person-years, respectively. Rates were ∼9 times higher in women than in men for prevalence (107.4 versus 12.5) and incidence (7.9 versus 1.0). Compared with non-Hispanic white women (64.3), prevalence was higher among non-Hispanic black (210.9), Hispanic (138.3), and non-Hispanic Asian (91.2) women. Incidence rates were higher among non-Hispanic black women (15.7) compared with non-Hispanic Asian (6.6), Hispanic (6.5), and non-Hispanic white (6.5) women. Capture-recapture adjustment increased the prevalence and incidence rates (75.9 and 6.0, respectively). Alternate SLE definitions without capture-recapture adjustment revealed higher age-standardized prevalence and incidence rates (73.8 and 6.2, respectively, by the SLICC definition and 72.6 and 5.0 by the rheumatologist definition) than the ACR definition, with similar patterns by sex and race/ethnicity.
CONCLUSION
The MLSP confirms findings from other registries on disparities by sex and race/ethnicity, provides new estimates among Asians and Hispanics, and provides estimates using the SLICC criteria.
目的
曼哈顿狼疮监测计划（MLSP）是一项基于人群的登记处，旨在确定 2007 年纽约县（曼哈顿）居民中系统性红斑狼疮（SLE）的患病率，以及 2007 年至 2009 年的发病率，并根据种族/族裔（包括亚洲人和西班牙裔人）对病例进行特征描述，因为缺乏这些数据。
方法
我们从医院记录、风湿病医生记录和行政数据库中确定了可能的 SLE 病例。病例根据美国风湿病学会（ACR）分类标准、系统性红斑狼疮国际合作诊所（SLICC）分类标准或治疗风湿病医生的诊断来定义。曼哈顿居民的发病率按年龄标准化，进行捕获-再捕获分析以评估病例的低估。
结果
根据 ACR 定义，SLE 的年龄标准化患病率和发病率分别为 62.2 和 4.6/10 万人年。患病率在女性中是男性的约 9 倍（107.4 比 12.5），发病率也是如此（7.9 比 1.0）。与非西班牙裔白人女性（64.3）相比，非西班牙裔黑人（210.9）、西班牙裔（138.3）和非西班牙裔亚裔（91.2）女性的患病率更高。与非西班牙裔亚裔（6.6）、西班牙裔（6.5）和非西班牙裔白人（6.5）女性相比，非西班牙裔黑人女性的发病率更高（15.7）。捕获-再捕获调整增加了患病率和发病率（分别为 75.9 和 6.0）。没有捕获-再捕获调整的替代 SLE 定义显示，患病率和发病率更高（SLICC 定义为 73.8 和 6.2，风湿病医生定义为 72.6 和 5.0），与 ACR 定义相似，按性别和种族/族裔划分的模式也相似。
结论
MLSP 证实了其他登记处关于性别和种族/族裔差异的发现，为亚洲人和西班牙裔人提供了新的估计，并使用 SLICC 标准提供了估计。
Zotero 插件