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纳米凝胶系统在局部麻醉剂给药中的应用。

Application of nanogel systems in the administration of local anesthetics.

作者信息

Tan Jeremy Pk, Tan Maureen Bh, Tam Michael Kc

机构信息

Institute of Bioengineering and Nanotechnology, Agency for Science Technology and Research, Singapore.

出版信息

Local Reg Anesth. 2010;3:93-100. doi: 10.2147/LRA.S7977. Epub 2010 Sep 1.

DOI:10.2147/LRA.S7977
PMID:22915875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3417954/
Abstract

Nanogels are robust nanoparticles that could be used to deliver active drug compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques. The strategy of using layer-by-layer approach to control the burst release of procaine hydrochloride (PrHy; a local anesthetic drug of the amino ester group) is described and discussed.

摘要

纳米凝胶是一种坚固的纳米颗粒，可用于可控药物递送应用中活性药物化合物的递送。本文综述了使用通过各种聚合技术制备的聚合物纳米颗粒来设计、合成、负载和释放局部麻醉剂的情况。描述并讨论了采用层层组装方法来控制盐酸普鲁卡因（PrHy；一种氨基酯类局部麻醉药）突释的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/8a9d8458734e/lra-3-093f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/ad01ec932fe6/lra-3-093f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/812bd86e3d1f/lra-3-093f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/2896b9f192a4/lra-3-093f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/445b772eaae4/lra-3-093f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/1da1c5a405d3/lra-3-093f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/8a9d8458734e/lra-3-093f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/ad01ec932fe6/lra-3-093f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/812bd86e3d1f/lra-3-093f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/2896b9f192a4/lra-3-093f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/445b772eaae4/lra-3-093f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/1da1c5a405d3/lra-3-093f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cae2/3417954/8a9d8458734e/lra-3-093f6.jpg

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Preparation and properties of carrageenan microspheres containing allopurinol and local anesthetic agents for the treatment of oral mucositis.
纳米凝胶作为一种用于脑癌的多功能药物递送系统。
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Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications.基于不同聚合物部分的用于生物医学应用的热响应纳米凝胶
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From micro- to nanostructured implantable device for local anesthetic delivery.从用于局部麻醉药递送的微结构到纳米结构可植入装置
Int J Nanomedicine. 2016 Jun 8;11:2695-709. doi: 10.2147/IJN.S99028. eCollection 2016.
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