Yao Chi, Yuan Ye, Yang Dayong
School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, People's Republic of China.
ACS Appl Bio Mater. 2018 Dec 17;1(6):2012-2020. doi: 10.1021/acsabm.8b00516. Epub 2018 Nov 14.
DNA polymeric materials possess many unique properties such as programmable molecular sequences and excellent biocompatibility and have demonstrated a high potential in an assortment of biomedical applications. Herein, a magnetic DNA nanogel is constructed, aiming at the applications of targeting drug delivery and triggered drug release. Centering on magnetic nanoparticles, a DNA nanogel layer is synthesized via rolling circle amplification, which equips abundant sites for the loading of anticancer drugs. Guided by an external magnetic field, the magnetic DNA nanogel can target tumor cells efficiently. Moreover, DNA nanogel is responsive to multistimuli including temperature, pH, and nuclease, enabling a controlled release of anticancer drugs. Our system achieves magnet-controlled delivery and stimuli-triggered drug release and provides a new strategy for the development of precision medicine.
DNA聚合材料具有许多独特的性质，如可编程的分子序列和优异的生物相容性，并已在多种生物医学应用中显示出巨大潜力。在此，构建了一种磁性DNA纳米凝胶，旨在用于靶向药物递送和触发药物释放应用。以磁性纳米颗粒为核心，通过滚环扩增合成了DNA纳米凝胶层，为抗癌药物的负载提供了丰富的位点。在外部磁场的引导下，磁性DNA纳米凝胶能够有效地靶向肿瘤细胞。此外，DNA纳米凝胶对包括温度、pH值和核酸酶在内的多种刺激具有响应性，能够实现抗癌药物的可控释放。我们的系统实现了磁控递送和刺激触发的药物释放，为精准医学的发展提供了一种新策略。
