类鼻疽杆菌对27种抗菌药物的体外敏感性
In vitro susceptibilities of Pseudomonas pseudomallei to 27 antimicrobial agents.
作者信息
Yamamoto T, Naigowit P, Dejsirilert S, Chiewsilp D, Kondo E, Yokota T, Kanai K
机构信息
Department of Bacteriology, School of Medicine, Juntendo University, Tokyo, Japan.
出版信息
Antimicrob Agents Chemother. 1990 Oct;34(10):2027-9. doi: 10.1128/AAC.34.10.2027.
Clinical isolates of Pseudomonas pseudomallei isolated in Thailand from 1981 to 1989 were tested for their in vitro susceptibilities to 27 antimicrobial agents, including older and newer quinolones, broad-spectrum cephems, carbapenems, monobactams, penicillins, tetracyclines, chloramphenicol, rifamycin, sulfamethoxazole, trimethoprim, and fosfomycin. Tosufloxacin, meropenem, CS-533, and minocycline were active against P. pseudomallei at levels comparable to or even greater than those of antimicrobial agents tested in previous studies, such as ciprofloxacin, ceftazidime, imipenem, carumonam, and piperacillin. Drug-resistant P. pseudomallei was found in only 1% of the isolates. The drug-resistant P. pseudomallei isolates displayed a unique pattern of susceptibility to the above-listed drugs.
对1981年至1989年在泰国分离出的类鼻疽假单胞菌临床分离株进行了检测，以测定它们对27种抗菌药物的体外敏感性，这些抗菌药物包括较老的和较新的喹诺酮类、广谱头孢菌素、碳青霉烯类、单环β-内酰胺类、青霉素类、四环素类、氯霉素、利福霉素、磺胺甲恶唑、甲氧苄啶和磷霉素。托氟沙星、美罗培南、CS-533和米诺环素对类鼻疽假单胞菌的活性与之前研究中测试的抗菌药物（如环丙沙星、头孢他啶、亚胺培南、卡芦莫南和哌拉西林）相当，甚至更高。仅在1%的分离株中发现了耐药类鼻疽假单胞菌。耐药类鼻疽假单胞菌分离株对上述药物呈现出独特的敏感性模式。
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