五种新型氟喹诺酮类药物对类鼻疽杆菌的活性。
Activities of five new fluoroquinolones against Pseudomonas pseudomallei.
作者信息
Winton M D, Everett E D, Dolan S A
机构信息
Division of Infectious Diseases, University of Missouri-Columbia 65212.
出版信息
Antimicrob Agents Chemother. 1988 Jun;32(6):928-9. doi: 10.1128/AAC.32.6.928.
Abstract
Thirty-four isolates of Pseudomonas pseudomallei were tested by a broth microdilution technique for susceptibility to amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin. Ciprofloxacin was the most active agent tested, with an MIC for 90% of the strains tested of 8 micrograms/ml. These in vitro results suggest that the fluoroquinolones tested would not be optimal for therapy of melioidosis.
摘要
采用肉汤微量稀释技术对34株类鼻疽假单胞菌进行测试，以检测其对阿米氟沙星、环丙沙星、依诺沙星、诺氟沙星和氧氟沙星的敏感性。环丙沙星是测试中活性最强的药物，90%受试菌株的最低抑菌浓度为8微克/毫升。这些体外实验结果表明，所测试的氟喹诺酮类药物并非治疗类鼻疽的最佳选择。
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