Department of Medical Informatics, Academic Medical Center, Amsterdam, the Netherlands.
Am J Obstet Gynecol. 2012 Oct;207(4):279.e1-7. doi: 10.1016/j.ajog.2012.07.026. Epub 2012 Jul 26.
The purpose of this study was to investigate the recurrence risk of preterm birth (<37 weeks' gestation) in a subsequent singleton pregnancy after a previous nulliparous preterm twin delivery.
We included 1957 women who delivered a twin gestation and a subsequent singleton pregnancy from the Netherlands Perinatal Registry. We compared the outcome of subsequent singleton pregnancy of women with a history of preterm delivery to the pregnancy outcome of women with a history of term twin delivery.
Preterm birth in the twin pregnancy occurred in 1075 women (55%) vs 882 women (45%) who delivered at term. The risk of subsequent spontaneous singleton preterm birth was significantly higher after preterm twin delivery (5.2% vs 0.8%; odds ratio, 6.9; 95% confidence interval, 3.1-15.2).
Women who deliver a twin pregnancy are at greater risk for delivering prematurely in a subsequent singleton pregnancy.
本研究旨在探讨既往无剖宫产史的早产（<37 周）双胎分娩后再次单胎妊娠的复发风险。
我们纳入了荷兰围产儿登记处的 1957 名分娩双胎妊娠和随后的单胎妊娠的女性。我们比较了有早产史的女性的后续单胎妊娠结局与有足月双胎分娩史的女性的妊娠结局。
1075 名（55%）孕妇的双胎妊娠早产，882 名（45%）孕妇足月分娩。与足月双胎分娩相比，早产双胎分娩后再次发生自发性单胎早产的风险显著增加（5.2% vs. 0.8%；优势比，6.9；95%置信区间，3.1-15.2）。
分娩双胎妊娠的女性在随后的单胎妊娠中早产的风险更高。
