Nutr Metab Cardiovasc Dis. 2012 Oct;22(10):819-22. doi: 10.1016/j.numecd.2012.08.005. Epub 2012 Aug 20.
Early diet and nutrition may set in place growth patterns and/or metabolic pathways that promote risk factors for later NCDs. Most relevant studies so far available have a cross-sectional or retrospective design and are thus of limited validity for evaluating the impact of early feeding on later disease. Standardised protocols for prospective research should be developed. The contribution of protein intake in early life to later NCD development has been the object of several studies; however future research should specifically target the effects of early protein intake on (a) how protein intake influences body composition, (b) how different body composition in infancy contributes to later NCDs, (c) whether there is an age 'window' when high protein intake is particularly associated with later overweight and obesity, (d) what levels of protein intake may protect against later overweight/obesity, (e) what level of cow milk intake in the first years of life minimises risk-inducing growth whilst meeting recommended calcium intakes. The role of the quality of fat and carbohydrate intakes at early ages should be better investigated. There is a dearth of data from many communities about the foods introduced as complementary feeds, the ages at which they are introduced and why mothers use these foods. Definitely more information is needed on how and to what extent mothers' behaviour is influenced by media, advertising and other commercial pressures and why formula fed infants are started on other foods much earlier than breast fed infants. Standardized protocols are needed to develop more data on complementary feeding in different regions, different countries and different socio-economic environments.
早期的饮食和营养可能会形成促进后期非传染性疾病风险因素的生长模式和/或代谢途径。到目前为止,大多数相关研究都具有横断面或回顾性设计,因此对于评估早期喂养对后期疾病的影响的有效性有限。应该制定用于前瞻性研究的标准化方案。在生命早期蛋白质摄入对后期非传染性疾病发展的影响已经是一些研究的对象;然而,未来的研究应该特别针对早期蛋白质摄入对(a)蛋白质摄入如何影响身体成分,(b)婴儿期不同的身体成分如何导致后期非传染性疾病,(c)是否存在高蛋白摄入与后期超重和肥胖特别相关的“窗口期”,(d)蛋白质摄入的何种水平可能预防后期超重/肥胖,(e)生命最初几年中摄入多少牛奶量可以最小化诱导生长的风险,同时满足推荐的钙摄入量。应该更好地研究生命早期脂肪和碳水化合物摄入质量的作用。关于补充食品的引入、引入的年龄以及母亲为何使用这些食品,许多社区的数据都非常缺乏。绝对需要更多关于母亲的行为如何受到媒体、广告和其他商业压力的影响以及为什么配方奶喂养的婴儿比母乳喂养的婴儿更早开始食用其他食物的信息,以及为什么配方奶喂养的婴儿比母乳喂养的婴儿更早开始食用其他食物。需要制定标准化方案,以便在不同地区、不同国家和不同社会经济环境中开发更多关于补充喂养的数据。