Nwokolo C U, Pounder R E
Academic Department of Medicine, Royal Free Hospital School of Medicine, London.
Br J Clin Pharmacol. 1990 Oct;30(4):648-50. doi: 10.1111/j.1365-2125.1990.tb03829.x.
Twenty-four urinary bismuth excretion was measured in five patients who had been treated with tripotassium dicitrato bismuthate, before and after single 1 g oral dose of D-penicillamine. Before dosing with D-penicillamine, the median 24 h urinary bismuth output was 55 micrograms 24 h-1 (range 17-156 micrograms 24 h-1) and following dosing with D-penicillamine the median 24 h urinary bismuth output was 53 micrograms 24 h-1 (range 12-156 micrograms 24 h-1). D-penicillamine does not facilitate the urinary excretion of bismuth, hence it is unsuitable for use as an oral chelator in patients with bismuth intoxication.
在5例曾用三钾二枸橼酸铋治疗的患者中，测定了单次口服1g D-青霉胺前后24小时尿铋排泄量。在给予D-青霉胺之前，24小时尿铋排泄量中位数为55微克/24小时（范围17 - 156微克/24小时），给予D-青霉胺后，24小时尿铋排泄量中位数为53微克/24小时（范围12 - 156微克/24小时）。D-青霉胺不能促进铋的尿排泄，因此它不适用于铋中毒患者作为口服螯合剂使用。
