Quinnan G V, Manischewitz J E
J Exp Med. 1979 Dec 1;150(6):1549-54. doi: 10.1084/jem.150.6.1549.
Definition of the functions by which the cellular immune system contributes to control of cytomegalovirus (CMV) infection should permit determination of the specific defects which result in the increased susceptibility to infection of immunosuppressed individuals. Using a murine model, we studied the cytotoxic lymphocyte response to murine CMV infection. This response was found to be biphasic. The initial phase extended from the 3rd to the 6th d after infection, was not genetically restricted, and correlated to a rise in numbers of natural killer (NK) and antibody-dependent killer (K) cells in spleens. The NK- and K-cell responses were preceded, by 24 h, by a rise in serum interferon levels, and occurred before the time when antibody could be measured in serum by neutralization. NK and K cells appear to develop the capacity for specific recognition of CMV-infected cells and the potential to contribute to control of the acute phase of CMV infection.
明确细胞免疫系统在控制巨细胞病毒（CMV）感染中所发挥的作用，应有助于确定导致免疫抑制个体对感染易感性增加的具体缺陷。我们使用小鼠模型研究了细胞毒性淋巴细胞对小鼠CMV感染的反应。发现这种反应是双相的。初始阶段从感染后第3天持续到第6天，不受基因限制，且与脾脏中自然杀伤（NK）细胞和抗体依赖性杀伤（K）细胞数量的增加相关。在NK细胞和K细胞反应出现的24小时前，血清干扰素水平会升高，且在血清中可通过中和试验检测到抗体之前就已发生。NK细胞和K细胞似乎具备了特异性识别CMV感染细胞的能力以及在控制CMV感染急性期方面发挥作用的潜力。
