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Latent cytomegalovirus infection of BALB/c mouse spleens detected by an explant culture technique.

作者信息

Wise T G, Manischewitz J E, Quinnan G V, Aulakh G S, Ennis F A

出版信息

J Gen Virol. 1979 Aug;44(2):551-6. doi: 10.1099/0022-1317-44-2-551.

DOI:10.1099/0022-1317-44-2-551
PMID:230295
Abstract

Latent murine cytomegalovirus (MCMV) infection of BALB/c mouse spleens was studied using several methods including an explant tissue culture technique, co-cultivation on allogeneic and syngeneic cell cultures and nucleic acid hybridization. BALB/c mice experience latent infection which persists for at least 6 months and involves only a small fraction of spleen cells. The explant culture technique proved to be much more sensitive than other methods for detecting latent infection of lymphoid tissues.

摘要

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