Irani Carla, Jammal Mouin, Asmar Gerard, Hajj Hanine, Halaby Georges
Hôtel-Dieu de France University Hospital Beirut, Lebanon.
J Med Liban. 2012 Apr-Jun;60(2):88-90.
Idiopathic chronic urticaria may be associated to other auto-immune diseases, in particular thyroiditis. The goal of our study is to show that this association is higher than the incidence of auto-immune thyroiditis in the general population.
It is a retrospective observational study including 90 patients with chronic urticaria. We calculated the proportion of patients having associated auto-immune thyroiditis based on a level of anti-TPO >220 mUI/ml.
The mean age of patients was 36.7 years with a sex ratio F/H of 2.9/1. The anti-TPO antibodies were positive in 16 patients (17.7%). Eight were euthyroid, seven had hypothyroidism and one had hyperthyroidism with positive anti-TSH receptor antibodies. The percentage of anti-TPO antibodies in the chronic urticaria patients was higher than the control group (17.7 vs. 8.7; p < 0.01).
This significant association between chronic urticaria and autoimmune thyroiditis may change the medical practice in Lebanon by including anti-TPO and anti-thyroglobulin antibodies in the workup of patients with chronic urticaria.
特发性慢性荨麻疹可能与其他自身免疫性疾病相关，尤其是甲状腺炎。我们研究的目的是表明这种关联高于普通人群中自身免疫性甲状腺炎的发病率。
这是一项回顾性观察研究，纳入了90例慢性荨麻疹患者。我们根据抗甲状腺过氧化物酶（anti-TPO）水平>220 mUI/ml计算出合并自身免疫性甲状腺炎的患者比例。
患者的平均年龄为36.7岁，女性与男性的性别比为2.9/1。16例患者（17.7%）的抗TPO抗体呈阳性。8例甲状腺功能正常，7例甲状腺功能减退，1例甲状腺功能亢进且抗促甲状腺激素受体抗体呈阳性。慢性荨麻疹患者中抗TPO抗体的百分比高于对照组（17.7%对8.7%；p<0.01）。
慢性荨麻疹与自身免疫性甲状腺炎之间的这种显著关联可能会改变黎巴嫩的医疗实践，即在慢性荨麻疹患者的检查中纳入抗TPO和抗甲状腺球蛋白抗体。
