Barth Charlotte, Straubinger Reinhard K, Sauter-Louis Carola, Hartmann Katrin
Clinic of Small Animal Medicine, LMU University of Munich, Germany.
Berl Munch Tierarztl Wochenschr. 2012 Jul-Aug;125(7-8):337-44.
Although prevalences of antibodies against Borrelia (B.) burgdorferi sensu lato (sl) and Anaplasma (A.) phagocytophilum have been reported to be high in the German dog population, the importance of the diseases caused by both agents is still not well characterized in a field situation.The aim of this study was (1) to determine the prevalence of antibodies to B. burgdorferi sl and A. phagocytophilum in dogs in Munich, Germany, and (2) to assess the clinical presentation and laboratory values of antibody-positive dogs and compare them to a negative control group. In total, 448 randomly selected dogs were screened for antibodies to B. burgdorferi sl and A. phagocytophilum with the SNAP 4Dx assay (IDEXX, Laboratories, Inc., USA). Dogs carrying antibodies against B. burgdorferi sl and/or A. phagocytophilum were classified as "positive"(n=100), the following 100 negative dogs served as control group. In both groups, physical examination and laboratory parameters were compared. 22 (4.9%) dogs had antibodies to B. burgdorferi sl, 78 (19.4%) to A. phagocytophilum, nine (2.0%) to both agents. Bernese Mountain Dogs had significantly more often antibodies against B. burgdorferi sl. Negative dogs were more often diagnosed as "healthy" compared to A. phagocytophilum antibody-positives that showed more often elevated body temperature and poor general condition; beyond that, there were no differences in clinical and laboratory abnormalities between both groups. Although dogs tested negative were more often considered healthy, there were no differences in parameters considered "specific" for both infections between dogs with and without antibodies. Hence, tests detecting antibodies against both agents are not able to detect animals with the clinical disease.
尽管据报道德国犬类群体中抗伯氏疏螺旋体狭义种（Borrelia burgdorferi sensu lato，sl）和嗜吞噬细胞无形体（Anaplasma phagocytophilum）抗体的流行率很高，但在实际情况中，这两种病原体所引起疾病的重要性仍未得到充分描述。本研究的目的是：（1）确定德国慕尼黑犬类中抗伯氏疏螺旋体狭义种和嗜吞噬细胞无形体抗体的流行率；（2）评估抗体阳性犬的临床表现和实验室检查值，并与阴性对照组进行比较。总共随机选取了448只犬，使用SNAP 4Dx检测法（美国IDEXX实验室公司）检测其抗伯氏疏螺旋体狭义种和嗜吞噬细胞无形体的抗体。携带抗伯氏疏螺旋体狭义种和/或嗜吞噬细胞无形体抗体的犬被归类为“阳性”（n = 100），接下来的100只阴性犬作为对照组。比较了两组的体格检查和实验室参数。22只（4.9%）犬有抗伯氏疏螺旋体狭义种抗体，78只（19.4%）有嗜吞噬细胞无形体抗体，9只（2.0%）对两种病原体均有抗体。伯恩山犬抗伯氏疏螺旋体狭义种抗体的比例显著更高。与嗜吞噬细胞无形体抗体阳性犬相比，阴性犬更常被诊断为“健康”，抗体阳性犬体温升高和一般状况较差更为常见；除此之外，两组在临床和实验室异常方面没有差异。尽管检测为阴性的犬更常被认为健康，但在有抗体和无抗体的犬之间，在两种感染的“特异性”参数方面没有差异。因此，检测这两种病原体抗体的检测方法无法检测出患有临床疾病的动物。
