El Hamiani Khatat Sarah, Daminet Sylvie, Duchateau Luc, Elhachimi Latifa, Kachani Malika, Sahibi Hamid
Department of Medicine, Surgery and Reproduction, Hassan II Institute of Agronomy and Veterinary Medicine, Rabat, Morocco.
Department of Companion Animals, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Front Vet Sci. 2021 Jun 23;8:686644. doi: 10.3389/fvets.2021.686644. eCollection 2021.
is a worldwide emerging zoonotic tick-borne pathogen transmitted by ticks and naturally maintained in complex and incompletely assessed enzootic cycles. Several studies have demonstrated an extensive genetic variability with variable host tropisms and pathogenicity. However, the relationship between genetic diversity and modified pathogenicity is not yet understood. Because of their proximity to humans, dogs are potential sentinels for the transmission of vector-borne pathogens. Furthermore, the strong molecular similarity between human and canine isolates of in Europe and the USA and the positive association in the distribution of human and canine cases in the USA emphasizes the epidemiological role of dogs. infects and survives within neutrophils by disregulating neutrophil functions and evading specific immune responses. Moreover, the complex interaction between the bacterium and the infected host immune system contribute to induce inflammatory injuries. Canine granulocytic anaplasmosis is an acute febrile illness characterized by lethargy, inappetence, weight loss and musculoskeletal pain. Hematological and biochemistry profile modifications associated with this disease are unspecific and include thrombocytopenia, anemia, morulae within neutrophils and increased liver enzymes activity. Coinfections with other tick-borne pathogens (TBPs) may occur, especially with , complicating the clinical presentation, diagnosis and response to treatment. Although clinical studies have been published in dogs, it remains unclear if several clinical signs and clinicopathological abnormalities can be related to this infection.
是一种全球范围内新出现的由蜱传播的人畜共患病原体，通过蜱传播，并在复杂且评估不完全的动物疫源循环中自然维持。多项研究表明其具有广泛的遗传变异性，宿主嗜性和致病性各不相同。然而，遗传多样性与致病性改变之间的关系尚不清楚。由于狗与人类接近，它们是媒介传播病原体传播的潜在哨兵。此外，欧洲和美国人类和犬类分离株之间强大的分子相似性以及美国人类和犬类病例分布的正相关性强调了狗的流行病学作用。通过扰乱中性粒细胞功能和逃避特异性免疫反应，在中性粒细胞内感染并存活。此外，细菌与受感染宿主免疫系统之间的复杂相互作用有助于诱导炎症损伤。犬粒细胞无形体病是一种急性发热性疾病，其特征为嗜睡、食欲不振、体重减轻和肌肉骨骼疼痛。与该疾病相关的血液学和生化指标改变不具有特异性，包括血小板减少、贫血、中性粒细胞内桑葚体以及肝酶活性增加。可能会发生与其他蜱传病原体（TBPs）的共感染，尤其是与，这会使临床表现、诊断和治疗反应复杂化。尽管已经发表了关于狗的临床研究，但尚不清楚几种临床症状和临床病理异常是否与这种感染有关。
