Needham G R, Sauer J R
J Parasitol. 1979 Aug;65(4):531-42.
Catecholamine-stimulated salivary fluid secretion (in vitro) by ixodid ticks is reduced by deletion or lowering the concentration of exogenous bathing medium Ca++. The Ca++ antagonist, verapamil, reversibly inhibits dopamine-stimulated secretion. Ionophore A-23187 is unable to induce glands to secrete. Studies in which labeled and unlabeled Ca++ flux were measured indicate that catecholamines induce release of calcium from intracellular stores during secretion. Cyclic AMP/theophylline-stimulated secretion is inhibited by verapamil, and the exclusion of calcium from the support medium. It is concluded that the primary catecholamine stimulus induces cyclic AMP formation and mobilization of Ca++ (intra- and extracellular). Cyclic AMP and calcium are thought to interact to control secretion within the fluid transporting cells of types II and III alveoli.
硬蜱儿茶酚胺刺激的唾液分泌（体外）会因外源性浴液中钙离子浓度的降低或缺失而减少。钙离子拮抗剂维拉帕米可可逆地抑制多巴胺刺激的分泌。离子载体A - 23187无法诱导腺体分泌。对标记和未标记钙离子通量的测量研究表明，儿茶酚胺在分泌过程中会诱导细胞内储存的钙释放。维拉帕米以及在支持培养基中去除钙离子可抑制环磷酸腺苷/茶碱刺激的分泌。得出的结论是，主要的儿茶酚胺刺激会诱导环磷酸腺苷的形成以及细胞内和细胞外钙离子的动员。环磷酸腺苷和钙离子被认为相互作用以控制II型和III型肺泡液体转运细胞内的分泌。
