van Beresteijn E C, van 't Hof M A, Schaafsma G, de Waard H, Duursma S A
Department of Nutrition, Netherlands Institute for Dairy Research, Ede.
Calcif Tissue Int. 1990 Dec;47(6):338-44. doi: 10.1007/BF02555884.
During an 8-year follow-up study, the effect of habitual dietary calcium intake on cortical bone loss in 154 healthy perimenopausal women was examined. Dietary calcium intake, determined by the cross-check dietary history method, and cortical bone mineral content of the radius were measured annually. Habitual dietary calcium intake was calculated as the mean of the estimated daily dietary calcium intake during the follow-up period. The women were classified according to their habitual calcium intake: those with an intake below 800 mg/day (n = 28), between 800 and 1350 mg/day (n = 95), and above 1350 mg/day (n = 31). The results show a continuous significant loss of cortical bone in all groups, amounting yearly to 1.3 +/- 0.25, 1.5 +/- 0.10, and 1.9 +/- 0.23% (mean +/- SE) for the groups with a low, medium, and high habitual calcium intake, respectively (P less than 0.01). The differences among the three groups did not reach statistical significance (P = 0.11). Body mass index was found to be positively correlated with the negative changes in cortical bone mineral density (r = 0.32, P less than 0.01), even after adjustments had been made for confounding factors. It is concluded that a habitual calcium intake exceeding 800 mg/day (the current Recommended Daily Allowance for adults) is ineffective in preventing cortical bone loss during early menopause. Body mass index is of major importance for the perimenopausal bone loss.
在一项为期8年的随访研究中，对154名健康围绝经期妇女习惯性膳食钙摄入量对皮质骨丢失的影响进行了研究。通过交叉核对饮食史方法确定膳食钙摄入量，并每年测量桡骨的皮质骨矿物质含量。习惯性膳食钙摄入量计算为随访期间估计每日膳食钙摄入量的平均值。根据习惯性钙摄入量对这些女性进行分类：摄入量低于800毫克/天的（n = 28），摄入量在800至1350毫克/天之间的（n = 95），以及摄入量高于1350毫克/天的（n = 31）。结果显示，所有组的皮质骨均持续显著丢失，习惯性钙摄入量低、中、高的组每年分别为1.3 +/- 0.25%、1.5 +/- 0.10%和1.9 +/- 0.23%（平均值 +/- 标准误）（P < 0.01）。三组之间的差异未达到统计学显著性（P = 0.11）。即使在对混杂因素进行调整后，发现体重指数与皮质骨矿物质密度的负变化呈正相关（r = 0.32，P < 0.01）。得出的结论是，习惯性钙摄入量超过800毫克/天（目前成年人的推荐每日摄入量）在预防绝经早期皮质骨丢失方面无效。体重指数对围绝经期骨质流失至关重要。
