• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

CARDIOSIM：首个用于心血管系统以及机械循环和通气支持模拟的意大利软件平台。

CARDIOSIM: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support.

作者信息

De Lazzari Beatrice, Badagliacca Roberto, Filomena Domenico, Papa Silvia, Vizza Carmine Dario, Capoccia Massimo, De Lazzari Claudio

机构信息

Department of Human Movement and Sport Sciences, "Foro Italico" 4th University of Rome, 00135 Rome, Italy.

Department of Clinical, Internal Anesthesiology and Cardiovascular Sciences, "Sapienza" University of Rome, 00185 Rome, Italy.

出版信息

Bioengineering (Basel). 2022 Aug 11;9(8):383. doi: 10.3390/bioengineering9080383.

DOI:10.3390/bioengineering9080383
PMID:36004908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9404951/
Abstract

This review is devoted to presenting the history of the CARDIOSIM software simulator platform, which was developed in Italy to simulate the human cardiovascular and respiratory systems. The first version of CARDIOSIM was developed at the Institute of Biomedical Technologies of the National Research Council in Rome. The first platform version published in 1991 ran on a PC with a disk operating system (MS-DOS) and was developed using the Turbo Basic language. The latest version runs on PC with Microsoft Windows 10 operating system; it is implemented in Visual Basic and C++ languages. The platform has a modular structure consisting of seven different general sections, which can be assembled to reproduce the most important pathophysiological conditions. One or more zero-dimensional (0-D) modules have been implemented in the platform for each section. The different modules can be assembled to reproduce part or the whole circulation according to Starling's law of the heart. Different mechanical ventilatory and circulatory devices have been implemented in the platform, including thoracic artificial lungs, ECMO, IABPs, pulsatile and continuous right and left ventricular assist devices, biventricular pacemakers and biventricular assist devices. CARDIOSIM is used in clinical and educational environments.

摘要

本综述致力于介绍CARDIOSIM软件模拟器平台的发展历程，该平台是在意大利开发的，用于模拟人体心血管和呼吸系统。CARDIOSIM的第一个版本是由罗马国家研究委员会生物医学技术研究所开发的。1991年发布的第一个平台版本运行在带有磁盘操作系统（MS-DOS）的个人电脑上，是使用Turbo Basic语言开发的。最新版本运行在装有微软Windows 10操作系统的个人电脑上；它是用Visual Basic和C++语言实现的。该平台具有模块化结构，由七个不同的通用部分组成，可以组合起来再现最重要的病理生理状况。每个部分在平台中都实现了一个或多个零维（0-D）模块。不同的模块可以根据心脏的斯塔林定律组合起来再现部分或整个循环。平台中还实现了不同的机械通气和循环装置，包括胸段人工肺、体外膜肺氧合（ECMO）、主动脉内球囊反搏（IABP）、搏动性和连续性左右心室辅助装置、双心室起搏器和双心室辅助装置。CARDIOSIM用于临床和教育环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/2c99a38b8252/bioengineering-09-00383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/df842ed5aa32/bioengineering-09-00383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/ecf83c567cfd/bioengineering-09-00383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/d812cbcb0a07/bioengineering-09-00383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/e58fe6063737/bioengineering-09-00383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/e5b74865609e/bioengineering-09-00383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/2c99a38b8252/bioengineering-09-00383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/df842ed5aa32/bioengineering-09-00383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/ecf83c567cfd/bioengineering-09-00383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/d812cbcb0a07/bioengineering-09-00383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/e58fe6063737/bioengineering-09-00383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/e5b74865609e/bioengineering-09-00383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b637/9404951/2c99a38b8252/bioengineering-09-00383-g006.jpg

相似文献

1
CARDIOSIM: The First Italian Software Platform for Simulation of the Cardiovascular System and Mechanical Circulatory and Ventilatory Support.CARDIOSIM：首个用于心血管系统以及机械循环和通气支持模拟的意大利软件平台。
Bioengineering (Basel). 2022 Aug 11;9(8):383. doi: 10.3390/bioengineering9080383.
2
ECMO Assistance during Mechanical Ventilation: Effects Induced on Energetic and Haemodynamic Variables.机械通气时的体外膜肺氧合辅助：对能量和血流动力学变量的影响。
Comput Methods Programs Biomed. 2021 Apr;202:106003. doi: 10.1016/j.cmpb.2021.106003. Epub 2021 Feb 14.
3
Interactive simulator for e-Learning environments: a teaching software for health care professionals.用于电子学习环境的交互式模拟器：一款面向医护专业人员的教学软件。
Biomed Eng Online. 2014 Dec 18;13:172. doi: 10.1186/1475-925X-13-172.
4
Mechanical ventilation and thoracic artificial lung assistance during mechanical circulatory support with PUCA pump: in silico study.机械循环支持中使用 PUCA 泵时的机械通气和胸腔人工肺辅助：计算机模拟研究。
Comput Methods Programs Biomed. 2014 Feb;113(2):642-54. doi: 10.1016/j.cmpb.2013.11.011. Epub 2013 Nov 26.
5
Right ventricular assistance by continuous flow device. A numerical simulation.连续流装置对右心室的辅助。数值模拟。
Methods Inf Med. 2007;46(5):530-7.
6
Computer simulation of haemodynamic parameters changes with left ventricle assist device and mechanical ventilation.左心室辅助装置和机械通气时血流动力学参数变化的计算机模拟
Comput Biol Med. 2000 Mar;30(2):55-69. doi: 10.1016/s0010-4825(99)00026-8.
7
Mock circulatory system for in vitro reproduction of the left ventricle, the arterial tree and their interaction with a left ventricular assist device.用于体外再现左心室、动脉树及其与左心室辅助装置相互作用的模拟循环系统。
J Med Eng Technol. 1994 May-Jun;18(3):87-95. doi: 10.3109/03091909409030237.
8
Computer simulation of coronary flow waveforms during caval occlusion.腔静脉闭塞期间冠状动脉血流波形的计算机模拟。
Methods Inf Med. 2009;48(2):113-22. doi: 10.3414/ME0539. Epub 2009 Feb 27.
9
A numerical model applied to the simulation of cardiovascular hemodynamics and operating condition of continuous-flow left ventricular assist device.应用于心血管血液动力学模拟和连续流左心室辅助装置操作条件的数值模型。
Math Biosci Eng. 2020 Oct 30;17(6):7519-7543. doi: 10.3934/mbe.2020384.
10
Reproduction of continuous flow left ventricular assist device experimental data by means of a hybrid cardiovascular model with baroreflex control.通过具有压力反射控制的混合心血管模型再现连续流左心室辅助装置的实验数据。
Artif Organs. 2014 Jun;38(6):456-68. doi: 10.1111/aor.12178. Epub 2013 Oct 1.

引用本文的文献

1
Review of Cardiovascular Mock Circulatory Loop Designs and Applications.心血管模拟循环回路设计与应用综述
Bioengineering (Basel). 2025 Aug 7;12(8):851. doi: 10.3390/bioengineering12080851.
2
Modelling and Simulation of the Interactions Between the Cardiovascular System and the Combined Use of VA ECMO and IABP: Comparison Between Peripheral and Central Configurations.心血管系统与VA体外膜肺氧合和主动脉内球囊反搏联合使用之间相互作用的建模与仿真：外周与中心配置的比较
Bioengineering (Basel). 2025 May 17;12(5):540. doi: 10.3390/bioengineering12050540.
3
Modelling and Simulation of the Combined Use of IABP and Impella as a Rescue Procedure in Cardiogenic Shock: An Alternative for Non-Transplant Centres?

本文引用的文献

1
Ventricular and Atrial Pressure-Volume Loops: Analysis of the Effects Induced by Right Centrifugal Pump Assistance.心室和心房压力-容积环：右心离心泵辅助诱导效应的分析
Bioengineering (Basel). 2022 Apr 20;9(5):181. doi: 10.3390/bioengineering9050181.
2
ECMO Assistance during Mechanical Ventilation: Effects Induced on Energetic and Haemodynamic Variables.机械通气时的体外膜肺氧合辅助：对能量和血流动力学变量的影响。
Comput Methods Programs Biomed. 2021 Apr;202:106003. doi: 10.1016/j.cmpb.2021.106003. Epub 2021 Feb 14.
3
Computer simulations can replace in-vivo experiments for implantable medical devices.
主动脉内球囊反搏（IABP）与Impella联合用于心源性休克抢救程序的建模与模拟：非移植中心的一种替代方案？
Bioengineering (Basel). 2023 Dec 17;10(12):1434. doi: 10.3390/bioengineering10121434.
计算机模拟可以替代植入式医疗设备的体内实验。
Phys Eng Sci Med. 2021 Mar;44(1):1-5. doi: 10.1007/s13246-021-00978-4. Epub 2021 Feb 8.
4
A numerical model applied to the simulation of cardiovascular hemodynamics and operating condition of continuous-flow left ventricular assist device.应用于心血管血液动力学模拟和连续流左心室辅助装置操作条件的数值模型。
Math Biosci Eng. 2020 Oct 30;17(6):7519-7543. doi: 10.3934/mbe.2020384.
5
Intra-aortic balloon counterpulsation timing: A new numerical model for programming and training in the clinical environment.主动脉内球囊反搏计时：一种新的数值模型，用于临床环境中的编程和培训。
Comput Methods Programs Biomed. 2020 Oct;194:105537. doi: 10.1016/j.cmpb.2020.105537. Epub 2020 May 15.
6
Mathematical modeling of cardiac function to evaluate clinical cases in adults and children.心脏功能的数学建模，用于评估成人和儿童的临床病例。
PLoS One. 2019 Oct 31;14(10):e0224663. doi: 10.1371/journal.pone.0224663. eCollection 2019.
7
How can LVAD support influence ventricular energetics parameters in advanced heart failure patients? A retrospective study.LVAD 支持如何影响晚期心力衰竭患者的心室能量学参数？一项回顾性研究。
Comput Methods Programs Biomed. 2019 Apr;172:117-126. doi: 10.1016/j.cmpb.2019.02.012. Epub 2019 Feb 23.
8
Simulation as a preoperative planning approach in advanced heart failure patients. A retrospective clinical analysis.模拟作为一种术前规划方法在晚期心力衰竭患者中的应用。一项回顾性临床分析。
Biomed Eng Online. 2018 May 2;17(1):52. doi: 10.1186/s12938-018-0491-7.
9
A patient-specific lumped-parameter model of coronary circulation.冠状动脉循环的患者特定集总参数模型。
Sci Rep. 2018 Jan 17;8(1):874. doi: 10.1038/s41598-018-19164-w.
10
A Re-Engineered Software Interface and Workflow for the Open-Source SimVascular Cardiovascular Modeling Package.用于开源SimVascular心血管建模软件包的重新设计的软件接口和工作流程。
J Biomech Eng. 2018 Feb 1;140(2):0245011-02450111. doi: 10.1115/1.4038751.