Department of Mechanical Engineering, Polytechnique Montreal, P.O. Box 6079, Montreal, Québec, H3C 3A7, Canada.
Research Center, Sainte-Justine University Health Center, Montreal, Canada.
Int J Cardiovasc Imaging. 2023 Dec;39(12):2589-2598. doi: 10.1007/s10554-023-02953-4. Epub 2023 Sep 20.
The characterization of cardiac mechanical properties may contribute to better understanding of doxorubicin-induced cardiotoxicity. Our study aims to investigate the relationship between cardiac mechanical properties, T1 and T2 relaxation times and partition coefficient. Fifty childhood acute lymphoblastic leukemia survivors underwent a cardiac magnetic resonance (CMR) at rest on a 3T MRI system and included a standard ECG-gated 3(3)3(3)5 MOLLI sequence for T1 mapping and an ECG-gated T2-prepared TrueFISP sequence for T2 mapping. Partition coefficient, ejection fraction, end-diastolic volume (EDV) and end-systolic volume (ESV) were calculated. CircAdapt model was used to study cardiac mechanical performance (left ventricle stiffness (LVS), contractility (LVC) and pressure (Pmin and Pmax), cardiac work efficiency (CWE) and ventricular arterial coupling). In the whole cohort, our results showed that LVC (R = 69.2%, r = 0.83), Pmin (R = 62.9%, r = 0.79) and Pmax can be predicted by significant CMR parameters, while T1 (R = 23.2%, r = 0.48) and partition coefficient (R = 13.8%, r = 0.37) can be predicted by significant cardiac mechanical properties. In SR group LVS (R = 94.8%, r = 0.97), LVC (R = 93.7%, r = 0.96) and Pmin (R = 90.6%, r = 0.95) can be predicted by significant cardiac mechanical properties, while in HR + DEX group CWE (R = 49.8%, r = 0.70) can be predicted by significant cardiac mechanical properties. Partition coefficient (R = 72.6%, r = 0.85) can be predicted by significant CMR parameters in SR group. Early characterization of cardiac mechanical properties from CMR parameters has the potential to early detect doxorubicin-induced cardiotoxicity.
心脏机械性能的特征可能有助于更好地理解多柔比星引起的心脏毒性。我们的研究旨在探讨心脏机械性能、T1 和 T2 弛豫时间和分配系数之间的关系。50 名儿童急性淋巴细胞白血病幸存者在 3T MRI 系统上进行了心脏磁共振（CMR）检查，包括标准心电图门控 3(3)3(3)5 MOLLI 序列进行 T1 映射和心电图门控 T2 准备 TrueFISP 序列进行 T2 映射。计算分配系数、射血分数、舒张末期容积（EDV）和收缩末期容积（ESV）。CircAdapt 模型用于研究心脏机械性能（左心室僵硬度（LVS）、收缩性（LVC）和压力（Pmin 和 Pmax）、心脏工作效率（CWE）和心室动脉耦合）。在整个队列中，我们的结果表明，LVC（R=69.2%，r=0.83）、Pmin（R=62.9%，r=0.79）和 Pmax 可以通过显著的 CMR 参数来预测，而 T1（R=23.2%，r=0.48）和分配系数（R=13.8%，r=0.37）可以通过显著的心脏机械性能来预测。在 SR 组中，LVS（R=94.8%，r=0.97）、LVC（R=93.7%，r=0.96）和 Pmin（R=90.6%，r=0.95）可以通过显著的心脏机械性能来预测，而在 HR+DEX 组中，CWE（R=49.8%，r=0.70）可以通过显著的心脏机械性能来预测。在 SR 组中，分配系数（R=72.6%，r=0.85）可以通过显著的 CMR 参数来预测。CMR 参数早期的心脏机械性能特征有可能早期检测多柔比星引起的心脏毒性。
