Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.
Virology. 2012 Nov 10;433(1):176-82. doi: 10.1016/j.virol.2012.08.003. Epub 2012 Aug 24.
In the spring of 2009, swine-origin influenza H1N1pdm09 viruses caused the first influenza pandemic of this century. We characterized the influenza viruses that circulated early during the outbreak in Mexico, including one newly sequenced swine H1N1pdm09 virus and three newly sequenced human H1N1pdm09 viruses that circulated in the outbreak of respiratory disease in La Gloria, Veracruz. Phylogenetic analysis revealed that the swine isolate (A/swine/Mexico/4/2009) collected in April 2009 is positioned in a branch that is basal to the rest of the H1N1pdm09 clade in two (NP and PA) of the eight single-gene trees. In addition, the concatenated HA-NA and the complete whole-genome trees also showed a basal position for A/swine/Mexico/4/2009. Furthermore, this swine virus was found to share molecular traits with non-H1N1pdm09 H1N1 viral lineages. These results suggest that this isolate could potentially be the first one detected from a sister lineage closely related to the H1N1pdm09 viruses.
2009 年春季，猪源 H1N1pdm09 病毒引发了本世纪的首次流感大流行。我们对墨西哥疫情早期流行的流感病毒进行了特征描述，包括一个新测序的猪源 H1N1pdm09 病毒和三个新测序的人源 H1N1pdm09 病毒，这些病毒在韦拉克鲁斯州拉格洛里亚的呼吸道疾病爆发中传播。系统进化分析显示，2009 年 4 月采集的猪源分离株（A/swine/Mexico/4/2009）在 8 个单基因树中的两个（NP 和 PA）中位于 H1N1pdm09 分支的基部。此外，HA-NA 串联和全基因组树也显示 A/swine/Mexico/4/2009 处于基部位置。此外，该猪源病毒与非 H1N1pdm09 H1N1 病毒谱系共享分子特征。这些结果表明，该分离株可能是首次从与 H1N1pdm09 病毒密切相关的姐妹谱系中检测到的。
