Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Vaccine. 2012 Oct 5;30(45):6389-95. doi: 10.1016/j.vaccine.2012.08.022. Epub 2012 Aug 22.
Acute exercise at the time of vaccination can enhance subsequent immune responses. However, the potential benefit of this effect will be its efficacy in boosting poor responses, and thus protection in at-risk populations. The current study tested the effect of exercise on the response to either a full- or half-dose Pneumococcal (Pn) vaccination to elicit stronger and weaker responses. Subjects were 133 young healthy adults, randomised to one of four groups: exercise or control task, receiving a full- or half-dose Pn vaccination. Prior to vaccination, exercise groups completed a 15 min arm and shoulder exercise task, control groups rested quietly. Antibody levels to 11 Pn strains were evaluated at baseline and 1-month. Across all participants, exercise groups showed significantly greater increase in antibody levels than control groups. When doses were compared, it emerged that those who exercised had significantly larger responses than those who rested in the half-dose group, but in the full-dose groups responses were similar. This data indicates the effectiveness of exercise as a vaccine adjuvant, particularly in weaker responses. Thus, given the potential public health benefits of no-cost behavioural intervention to enhance response to vaccination, testing in at-risk populations should be pursued.
在接种疫苗时进行急性运动可以增强随后的免疫反应。然而，这种效果的潜在益处将是其增强弱反应的功效，从而为高危人群提供保护。本研究测试了运动对全剂量或半剂量肺炎球菌（Pn）疫苗接种反应的影响，以引发更强和更弱的反应。受试者为 133 名年轻健康成年人，随机分为四组：运动或对照任务，接受全剂量或半剂量 Pn 疫苗接种。在接种疫苗之前，运动组完成了 15 分钟的手臂和肩部运动任务，对照组安静休息。在基线和 1 个月时评估了对 11 种肺炎球菌菌株的抗体水平。在所有参与者中，运动组的抗体水平增加明显高于对照组。当比较剂量时，运动组在半剂量组中的反应明显大于休息组，但在全剂量组中的反应相似。该数据表明运动作为疫苗佐剂的有效性，特别是在较弱的反应中。因此，鉴于无需成本的行为干预措施增强疫苗接种反应的潜在公共卫生益处，应在高危人群中进行测试。
