Department of Urology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Fertil Steril. 2012 Dec;98(6):1428-31. doi: 10.1016/j.fertnstert.2012.07.1130. Epub 2012 Aug 24.
To quantify the effect of the new 2010 World Health Organization (WHO) semen analysis reference values on reclassifying previous semen analysis parameters and definition of patients with male factor infertility.
A multi-institutional retrospective chart review.
University and private male infertility clinics.
PATIENT(S): Men referred for infertility evaluation.
INTERVENTION(S): Comparison of semen analysis values based on 2010 versus 1999 reference criteria.
MAIN OUTCOME MEASURE(S): Quantification of the change based on individual sperm parameters and as a whole.
RESULT(S): A total of 184 men had at least two semen analyses; 13 (7%), 17 (9.2%), 34 (18.4%), and 29 (15.7%) patients changed classification to being at or above the reference values by the 2010 criteria for semen volume, sperm concentration, motility, and morphology, respectively. A total of 501 men had one semen analysis on file; 40 (7.9%), 31 (6.2%), 50 (9.9%), and 74 (19.3%) would change classification for volume, concentration, motility, and morphology, respectively. Overall, 103 patients (15.1%) who had one or more parameter below the reference value on the original analysis were converted to having all parameters at or above the 2010 reference values.
CONCLUSION(S): The 2010 reference values result in some infertile men being reclassified as fertile if status is based on semen analysis alone. This may lead to fewer men being referred for proper infertility evaluation or treatment.
定量评估新的 2010 年世界卫生组织（WHO）精液分析参考值对重新分类既往精液分析参数和男性因素不育定义的影响。
多机构回顾性图表审查。
大学和私人男性不育诊所。
因不育评估而就诊的男性。
比较基于 2010 年和 1999 年参考标准的精液分析值。
根据个体精子参数和整体情况量化变化。
共有 184 名男性至少进行了两次精液分析；分别有 13 名（7%）、17 名（9.2%）、34 名（18.4%）和 29 名（15.7%）患者的精液量、精子浓度、活力和形态分类根据 2010 年标准达到或超过参考值。共有 501 名男性的档案中只有一次精液分析；分别有 40 名（7.9%）、31 名（6.2%）、50 名（9.9%）和 74 名（19.3%）患者的精液量、浓度、活力和形态分类根据新标准将改变。总体而言，在原始分析中，有一个或多个参数低于参考值的 103 名患者被转换为所有参数均达到或超过 2010 年参考值。
如果仅基于精液分析来判断，2010 年参考值可能导致一些不育男性被重新归类为生育能力正常。这可能导致较少的男性被转介进行适当的不育评估或治疗。
