基质金属蛋白酶-9升高与男性不育中的白细胞介素-17及心理压力相关：一项横断面研究。
Matrix metalloproteinase-9 is elevated and related to interleukin-17 and psychological stress in male infertility: A cross-sectional study.
作者信息
Mary Ann Prasad, Nandeesha Hanumanthappa, Papa Dasari, Chitra Thyagaraju, Ganesh Rajesh Nachiappa, Menon Vikas
机构信息
Biochemistry Department, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
出版信息
Int J Reprod Biomed. 2021 Apr 22;19(4):333-338. doi: 10.18502/ijrm.v19i4.9059. eCollection 2021 Apr.
BACKGROUND
Matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17) and psychological stress are known to play a role in the pathogenesis of male infertility.
OBJECTIVE
To assess the association of MMP-9 with IL-17 and psychological stress in infertile men.
MATERIALS AND METHODS
In this cross-sectional study, 39 men with infertility diagnosed based on semen analysis and 39 subjects with normal semen analysis were included in the study. MMP-9 and IL-17 were estimated in both groups by ELISA. Perceived stress scale was used to assess psychological stress in controls and cases.
RESULTS
In infertile cases, MMP-9 and IL-17 were significantly increased when compared with controls (p = 0.046, p = 0.041 respectively). A significant association of MMP-9 was observed with IL-17 (r = 0.335, p = 0.037) and perceived stress scale (r = 0.329, p = 0.041).
CONCLUSION
IL-17 and stress increase MMP- 9 levels in infertile men.
背景
已知基质金属蛋白酶-9（MMP-9）、白细胞介素-17（IL-17）和心理压力在男性不育的发病机制中起作用。
目的
评估不育男性中MMP-9与IL-17及心理压力之间的关联。
材料与方法
在这项横断面研究中，纳入了39例根据精液分析诊断为不育的男性和39例精液分析正常的受试者。两组均采用酶联免疫吸附测定法（ELISA）检测MMP-9和IL-17。采用感知压力量表评估对照组和病例组的心理压力。
结果
与对照组相比，不育病例组的MMP-9和IL-17显著升高（分别为p = 0.046，p = 0.041）。观察到MMP-9与IL-17（r = 0.335，p = 0.037）及感知压力量表（r = 0.329，p = 0.041）之间存在显著关联。
结论
IL-17和压力会增加不育男性的MMP-9水平。
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