Elberger A J
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.
Exp Brain Res. 1990;82(3):617-27. doi: 10.1007/BF00228803.
Following section of the corpus callosum at 1-6 postnatal weeks in cats, behavioral visual acuity was measured binocularly and monocularly from 6-29 postnatal weeks; physiological determination of spatial frequency thresholds of single striate cortical cells was performed when the cats were at least 8 months old. Results were compared between cats with callosum section at each postnatal week, as well as with normal cats. Cats with callosotomy at 1-3 postnatal weeks had deficits in behavioral visual acuity, and the deficits were greatest in the youngest operated cats. Cats with callosotomy at 1-2 postnatal weeks failed to resolve as high spatial frequencies as did normal cats, and the resolution of the 1 week operated cats was lower than the resolution of the 2 week operated cats. Cats with callosotomy at 3-6 postnatal weeks had spatial frequency thresholds that were equivalent to those of normal cats. To determine what kinds of striate cells had reduced spatial resolution following neonatal corpus callosum section, cells were categorized according to class (Simple, Complex), receptive field location (Central, Peripheral), and monocular behavioral acuity eye performance (Better Eye, Worse Eye). Cats with corpus callosum section during postnatal week 1 had the lowest spatial resolution for all cell categories compared to all groups tested. However, cats with callosum section during postnatal week 2 had normal spatial frequency thresholds for Simple, Central and Better Eye categories. The cats with callosum section in postnatal weeks 3-6 had normal spatial frequency thresholds for all cell categories. For corpus callosum sectioned cats with and without visual deficits, and for normal cats, visual acuity measured behaviorally is significantly related to visual acuity measured physiologically. The results show that neonatal corpus callosum section in cats can affect behavioral visual acuity, as well as the spatial frequency thresholds of many categories of striate cortical cells. However, callosum section at different ages affects different populations of cortical cells. Furthermore, the results suggest that neonatal corpus callosum section may directly affect a single fundamental property of cells in primary visual cortex with a resulting disruption of many visual functions.
在出生后1 - 6周切断猫的胼胝体，在出生后6 - 29周用双眼和单眼测量行为视敏度；当猫至少8个月大时，对单个纹状皮质细胞的空间频率阈值进行生理学测定。将出生后各周进行胼胝体切断的猫与正常猫的结果进行比较。出生后1 - 3周进行胼胝体切断术的猫在行为视敏度方面存在缺陷，且在最年幼的手术猫中缺陷最为明显。出生后1 - 2周进行胼胝体切断术的猫无法分辨像正常猫那样高的空间频率，且出生后1周手术的猫的分辨能力低于出生后2周手术的猫。出生后3 - 6周进行胼胝体切断术的猫的空间频率阈值与正常猫相当。为了确定新生儿胼胝体切断术后哪些类型的纹状细胞空间分辨率降低，根据细胞类别（简单型、复杂型）、感受野位置（中央、周边）以及单眼行为视敏度眼表现（优势眼、劣势眼）对细胞进行分类。与所有测试组相比，出生后第1周进行胼胝体切断术的猫在所有细胞类别中空间分辨率最低。然而，出生后第2周进行胼胝体切断术的猫在简单型、中央型和优势眼类别中空间频率阈值正常。出生后3 - 6周进行胼胝体切断术的猫在所有细胞类别中空间频率阈值正常。对于有和没有视觉缺陷的胼胝体切断术猫以及正常猫，行为测量的视敏度与生理学测量的视敏度显著相关。结果表明，猫的新生儿胼胝体切断术会影响行为视敏度以及许多类别纹状皮质细胞的空间频率阈值。然而，不同年龄进行胼胝体切断术会影响不同的皮质细胞群体。此外，结果表明新生儿胼胝体切断术可能直接影响初级视觉皮层中细胞的单一基本特性，从而导致许多视觉功能的破坏。
