National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, United States.
Glycan and Life Systems Integration Center, Soka University, 1-236 Tangi-machi, Hachioji, Tokyo 192-8577, Japan.
Glycobiology. 2023 Jun 21;33(6):454-463. doi: 10.1093/glycob/cwad028.
The GlyCosmos Glycoscience Portal (https://glycosmos.org) and PubChem (https://pubchem.ncbi.nlm.nih.gov/) are major portals for glycoscience and chemistry, respectively. GlyCosmos is a portal for glycan-related repositories, including GlyTouCan, GlycoPOST, and UniCarb-DR, as well as for glycan-related data resources that have been integrated from a variety of 'omics databases. Glycogenes, glycoproteins, lectins, pathways, and disease information related to glycans are accessible from GlyCosmos. PubChem, on the other hand, is a chemistry-based portal at the National Center for Biotechnology Information. PubChem provides information not only on chemicals, but also genes, proteins, pathways, as well as patents, bioassays, and more, from hundreds of data resources from around the world. In this work, these 2 portals have made substantial efforts to integrate their complementary data to allow users to cross between these 2 domains. In addition to glycan structures, key information, such as glycan-related genes, relevant diseases, glycoproteins, and pathways, was integrated and cross-linked with one another. The interfaces were designed to enable users to easily find, access, download, and reuse data of interest across these resources. Use cases are described illustrating and highlighting the type of content that can be investigated. In total, these integrations provide life science researchers improved awareness and enhanced access to glycan-related information.
GlyCosmos 糖科学门户（https://glycosmos.org）和 PubChem（https://pubchem.ncbi.nlm.nih.gov/）分别是糖科学和化学的主要门户。GlyCosmos 是与聚糖相关的存储库的门户，包括 GlyTouCan、GlycoPOST 和 UniCarb-DR，以及从各种“组学”数据库集成的聚糖相关数据资源。GlyCosmos 提供与聚糖相关的糖基因、糖蛋白、凝集素、途径和疾病信息。另一方面，PubChem 是国家生物技术信息中心的一个基于化学的门户。PubChem 不仅提供有关化学物质的信息，还提供来自全球数百个数据资源的基因、蛋白质、途径以及专利、生物测定等信息。在这项工作中，这两个门户都做出了巨大努力，整合了它们互补的数据，以便用户在这两个领域之间进行交叉查询。除了聚糖结构外，还整合和相互链接了与聚糖相关的基因、相关疾病、糖蛋白和途径等关键信息。界面的设计使用户能够轻松地在这些资源中查找、访问、下载和重复使用感兴趣的数据。通过使用案例说明了可以研究的内容类型。总之，这些整合为生命科学研究人员提供了更好的聚糖相关信息意识和增强的访问权限。
