Institute for Cardiovascular Prevention, University Clinic of the Ludwig-Maximilians-University of Munich, Munich, Germany.
J Leukoc Biol. 2012 Dec;92(6):1167-75. doi: 10.1189/jlb.0312151. Epub 2012 Aug 24.
Platelets play a crucial role in the physiology of the primary hemostasis and in the pathophysiological activity of arterial thrombosis, provide rapid protection against bleeding, and catalyze the formation of stable blood clots via the coagulation cascade. Over the past years, it has become clear that platelets are important, not only in hemostasis and thrombosis but also in inflammation and in distinct aspects of atherosclerosis. Nowadays, platelets are known to have a large variety of functions. Platelets are able to interact with a large variety of cell types, such as leukocytes, endothelial cells, and SMCs, and these interactions have been implicated in the pathophysiology of vascular inflammation. In addition, platelets carry a highly inflammatory payload and are able to transport, synthesize, and deposit cytokines, chemokines, and lipid mediators, thereby initiating and propagating atherosclerotic disease. In this review, the current state of the art of the proinflammatory functions in the context of atherosclerotic cardiovascular disease will be outlined.
血小板在初级止血的生理学和动脉血栓形成的病理生理活性中起着至关重要的作用，通过凝血级联反应迅速提供止血保护，并促进稳定血栓的形成。在过去的几年中，人们已经清楚地认识到，血小板不仅在止血和血栓形成中，而且在炎症和动脉粥样硬化的各个方面都起着重要作用。如今，已知血小板具有多种功能。血小板能够与多种细胞类型相互作用，如白细胞、内皮细胞和 SMC 等，这些相互作用与血管炎症的病理生理学有关。此外，血小板携带高度炎症的有效载荷，能够运输、合成和沉积细胞因子、趋化因子和脂质介质，从而引发和促进动脉粥样硬化疾病。在这篇综述中，将概述动脉粥样硬化性心血管疾病背景下血小板的促炎功能的最新研究进展。
