Vijayakumar M, Eswaran M Bavani, Ojha S K, Rao Ch V, Rawat A K S
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Partap Marg, Lucknow-226 001, India.
Indian J Pharm Sci. 2011 Sep;73(5):572-7. doi: 10.4103/0250-474X.99018.
The present study was carried out to evaluate antiulcer activity of hydroalcohol extract of Momordica dioica Roxb. fruit. Momordica dioica Roxb. fruit extract (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 days for prevention from ethanol, cold-restraint stress and pylorus ligation-induced ulcers. Estimation of H(+)-K(+) ATPase activity and gastric wall mucous were performed in ethanol-induced ulcer model, antioxidant enzyme activities was carried out in cold-restraint stress-induced ulcer model, and various gastric secretion parameters like volume of gastric juice, acid output, and pH value were estimated in pylorus ligation-induced ulcer model. A significant reduction in lesion index was observed in ulcer-induced animals pre treated with extract at different doses when compared with ulcerated rats in all models. A significant decrease occurred in the level of H(+)-K(+) ATPase, volume of gastric juice, and acid output. Gastric wall mucus and pH were increased significantly. These showed dose-dependent action of extract. LPO and antioxidant enzyme levels of SOD were decreased, but CAT enzyme showed significant increase. Thus the results indicate that the Momordica dioica extract possess antiulcerogenic effect, that attributable to augmentation of gastric defense mechanisms.
本研究旨在评估苦瓜（Momordica dioica Roxb.）果实水醇提取物的抗溃疡活性。将苦瓜果实提取物（100、200和400mg/kg体重）口服给药，每日两次，持续5天，以预防乙醇、冷束缚应激和幽门结扎诱导的溃疡。在乙醇诱导的溃疡模型中测定H(+)-K(+) ATP酶活性和胃壁黏液，在冷束缚应激诱导的溃疡模型中检测抗氧化酶活性，并在幽门结扎诱导的溃疡模型中评估各种胃分泌参数，如胃液体积、酸分泌量和pH值。与所有模型中的溃疡大鼠相比，不同剂量提取物预处理的溃疡诱导动物的损伤指数显著降低。H(+)-K(+) ATP酶水平、胃液体积和酸分泌量显著下降。胃壁黏液和pH值显著升高。这些结果表明提取物具有剂量依赖性作用。脂质过氧化（LPO）水平降低，超氧化物歧化酶（SOD）等抗氧化酶水平降低，但过氧化氢酶（CAT）活性显著增加。因此，结果表明苦瓜提取物具有抗溃疡作用，这归因于胃防御机制增强。
