Hoffman Abigail, Pellenberg Rod, Drendall Catherine Ibarra, Seewaldt Victoria
Curr Breast Cancer Rep. 2012 Sep;4(3):180-187. doi: 10.1007/s12609-012-0081-9. Epub 2012 Jun 22.
Random periareolar fine needle aspiration (RPFNA) and ductal lavage (DL) are research techniques developed to (1) assess short-term breast cancer risk in asymptomatic women who are at increased risk for breast cancer and (2) track cytological response to risk reduction strategies. RPFNA and DL provide minimally invasive methods to repeatedly sample epithelial cells and research tools to investigate the biological origins of breast cancer in high-risk women. This review gives an overview of the strengths and limitations of both RPFNA and DL for risk assessment and breast cancer prevention in asymptomatic high-risk women.
随机乳晕周围细针穿刺抽吸术（RPFNA）和导管灌洗术（DL）是为以下目的而开发的研究技术：（1）评估无症状但患乳腺癌风险增加的女性的短期乳腺癌风险；（2）追踪细胞对风险降低策略的反应。RPFNA和DL提供了微创方法来反复采集上皮细胞，以及研究工具来调查高危女性乳腺癌的生物学起源。本综述概述了RPFNA和DL在无症状高危女性风险评估和乳腺癌预防方面的优势和局限性。
