Zakerinia M, Namdari M, Amirghofran S
Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran Red Crescent Med J. 2012 Jun;14(6):337-44. Epub 2012 Jun 30.
The etiology of malignant lymphoma is still largely unknown. This study determines the relationship between exposure to pesticides and the occurrence of lymphoid neoplasms in Shiraz, Southern Iran.
Between 2007 and 2008, in a case control study conducted in Nemazee Hospital in Shiraz, Southern Iran, 200 subjects diagnosed with lymphoma according to the World Health Organization (WHO) classification were enrolled. Controls (n=200) were frequency matched to the cases by sex, age, and center. Subjects who were a farmer were compared with all other occupations.
Out of the 200 cases that were diagnosed as lymphoid neoplasms, 100 were non-Hodgkin's lymphoma, 54 Hodgkin's lymphoma and 46 multiple myeloma. Seventy two percent of the NHL's were of the B-cell type, 15% of the T-cell type and the rest were not classified. Furthermore, subjects exposed to pesticides were at an increased risk of non-Hodgkin lymphoma and MM, but not Hodgkin lymphoma.
Risk of non-Hodgkin lymphoma and MM was highest for exposure to pesticides, among them, insecticide's risk was confirmed.
恶性淋巴瘤的病因在很大程度上仍不明确。本研究确定了伊朗南部设拉子地区接触农药与淋巴瘤发生之间的关系。
2007年至2008年期间，在伊朗南部设拉子的内马齐医院进行了一项病例对照研究，纳入了200名根据世界卫生组织（WHO）分类诊断为淋巴瘤的患者。对照组（n = 200）按性别、年龄和中心与病例进行频率匹配。将农民与所有其他职业的受试者进行比较。
在诊断为淋巴瘤的200例患者中，100例为非霍奇金淋巴瘤，54例为霍奇金淋巴瘤，46例为多发性骨髓瘤。非霍奇金淋巴瘤的72%为B细胞型，15%为T细胞型，其余未分类。此外，接触农药的受试者患非霍奇金淋巴瘤和多发性骨髓瘤的风险增加，但患霍奇金淋巴瘤的风险未增加。
接触农药患非霍奇金淋巴瘤和多发性骨髓瘤的风险最高，其中杀虫剂的风险得到证实。
