Urology and Nephrology Research Center (UNRC), Shohada Medical Center, Shahid Beheshti University of Medical Science , Tehran, Iran.
Arch Iran Med. 2012 Sep;15(9):572-4.
Cervical cancer is one of the most common tumors in women. One of its risk factors is direct contact with viruses, in particular human papillomavirus (HPV). Recent studies have shown a prevalence of 2%-35% for HPV in cases with bladder cancer. In addition, some malignancies of the urogenital organs in males may promote the probability of cervical cancer in their spouses. In this study, the relationship between cervical dysplasia in women and evidence of HPV infection in tissue specimens obtained from their spouses' bladders has been investigated.
This cross-sectional study was conducted on 82 male patients with bladder tumors and their spouses between February 2004 and February 2007 in Tehran. We gathered data related to the histopathology of the transitional cell carcinoma (TCC) in men and Pap smear tests of their spouses. Tissue specimens of patients with bladder TCC were analyzed for HPV infection using polymerase chain reaction (PCR). HPV-positive specimens were tested for subtypes 16 and 18.
In 24 (29.3%) men, bladder tumor samples were positive for HPV infection. Of these, we found HPV-18 infection in 9 (37.5%), while 3 (12.5%) were infected with HPV-16. In the spouses of those men with HPV-infected bladder tumors, 4 (4.9%) cases had cellular dysplasia noted on their Pap smear tests. We found no dysplasia in those women whose husbands had bladder TCC, but no HPV infection (P = 0.006).
It is possible to decrease the incidence of bladder TCC in men and cervical cancer in women through public education regarding the methods of transmission and avoidance of risky sexual behaviors.
宫颈癌是女性最常见的肿瘤之一。其危险因素之一是与病毒的直接接触，特别是人乳头瘤病毒（HPV）。最近的研究表明，膀胱癌病例中 HPV 的患病率为 2%-35%。此外，男性泌尿生殖器官的一些恶性肿瘤可能会增加其配偶患宫颈癌的概率。在这项研究中，我们调查了女性宫颈发育不良与配偶膀胱组织标本中 HPV 感染证据之间的关系。
这是 2004 年 2 月至 2007 年 2 月在德黑兰进行的一项横断面研究，共纳入 82 名男性膀胱癌患者及其配偶。我们收集了与男性膀胱移行细胞癌（TCC）组织病理学相关的数据以及其配偶巴氏涂片检查的数据。使用聚合酶链反应（PCR）分析膀胱癌患者的组织标本是否存在 HPV 感染。对 HPV 阳性标本进行 16 型和 18 型亚型检测。
在 24 名（29.3%）男性中，膀胱肿瘤样本 HPV 感染呈阳性。其中，HPV-18 感染 9 例（37.5%），HPV-16 感染 3 例（12.5%）。在 HPV 感染膀胱肿瘤男性的配偶中，4 名（4.9%）巴氏涂片检查发现细胞发育不良。我们在那些丈夫患有膀胱癌但没有 HPV 感染的女性中没有发现发育不良（P = 0.006）。
通过对传播途径和避免危险性行为的公众教育，可能会降低男性膀胱癌和女性宫颈癌的发病率。
