Expert Opin Drug Deliv. 2012 Nov;9(11):1325-32. doi: 10.1517/17425247.2012.717927. Epub 2012 Aug 28.
Several microbes have evolved clinically significant resistance against almost every available antibiotic. Yet the development of new classes of antibiotics has lagged far behind our growing need. Frequent and suboptimal use of antibiotics particularly in developing countries aggravated the problem by increasing the rate of resistance. Therefore, developing new and multidimensional strategies to combat microbial infections is warranted. These include i) modification of existing antibiotics, ii) searching new and novel antibiotics, iii) development and improvement of antibiotics carrier system to reduce amount and frequency of antibiotic doses, iv) development of targeted antibiotic delivery systems. Here, the authors discuss trends and development of nano-materials and alternative antimicrobials to solve the problem of antibiotic resistance.
许多微生物已经进化出对几乎所有现有抗生素的临床显著耐药性。然而，新抗生素类别的开发远远落后于我们日益增长的需求。抗生素的频繁和不适当使用，特别是在发展中国家，通过增加耐药率加剧了这个问题。因此，有必要制定新的、多方面的策略来对抗微生物感染。这些策略包括：i）现有抗生素的修饰，ii）寻找新的和新颖的抗生素，iii）开发和改进抗生素载体系统以减少抗生素剂量的数量和频率，iv）开发靶向抗生素递送系统。在这里，作者讨论了纳米材料和替代抗菌剂的趋势和发展，以解决抗生素耐药性问题。
