Jiangsu Vocational College of Medicine, Yancheng, China.
School of Graduate Studies, Management and Science University, Shah Alam, Malaysia.
Arch Microbiol. 2023 Oct 20;205(11):356. doi: 10.1007/s00203-023-03699-2.
The emergence and transmission of antibiotic resistance is a global public health crisis with significant burden on healthcare systems, resulting in high mortality and economic costs. In 2019, almost five million deaths were associated with drug-resistant infections, and if left unchecked, the global economy could lose $100 trillion by 2050. To effectively combat this crisis, it is essential for all countries to understand the current situation of antibiotic resistance. In this review, we examine the current driving factors leading to the crisis, impact of critical superbugs in three regions, and identify novel mechanisms of antibiotic resistance. It is crucial to monitor the phenotypic characteristics of drug-resistant pathogens and describe the mechanisms involved in preventing the emergence of cross-resistance to novel antimicrobials. Additionally, maintaining an active pipeline of new antibiotics is essential for fighting against diverse antibiotic-resistant pathogens. Developing antibacterial agents with novel mechanisms of action is a promising way to combat increasing antibiotic-resistant pathogens.
抗生素耐药性的出现和传播是一个全球性的公共卫生危机，给医疗系统带来了巨大的负担，导致高死亡率和经济成本。2019 年，近 500 万人的死亡与耐药性感染有关，如果不加以控制，到 2050 年，全球经济可能损失 100 万亿美元。为了有效应对这一危机，所有国家都必须了解抗生素耐药性的现状。在这篇综述中，我们研究了导致这一危机的当前驱动因素、三个地区关键超级细菌的影响，并确定了抗生素耐药性的新机制。监测耐药性病原体的表型特征并描述防止新型抗菌药物出现交叉耐药的机制至关重要。此外，保持新抗生素的积极研发管道对于对抗各种抗生素耐药性病原体至关重要。开发具有新型作用机制的抗菌药物是对抗不断增加的抗生素耐药性病原体的有前途的方法。
