Department of Neurobiology, University of Alabama, Birmingham, Alabama 35294, United States.
Nano Lett. 2012 Sep 12;12(9):4742-7. doi: 10.1021/nl302178s. Epub 2012 Aug 30.
We report the use of chemically functionalized water-soluble single-walled carbon nanotubes (ws-SWCNTs) for the modulation of morpho-functional characteristics of astrocytes. When added to the culturing medium, ws-SWCNTs were able to make astrocytes larger and stellate/mature, changes associated with the increase in glial fibrillary acidic protein immunoreactivity. Thus, ws-SWCNTs could have more beneficial effects at the injury site than previously thought; by affecting astrocytes, they could provide for a more comprehensive re-establishment of the brain computational power.
我们报告了使用化学功能化的水溶性单壁碳纳米管（ws-SWCNTs）来调节星形胶质细胞的形态和功能特性。当添加到培养介质中时，ws-SWCNTs 能够使星形胶质细胞变大并呈星状/成熟，这与神经胶质纤维酸性蛋白免疫反应性的增加有关。因此，ws-SWCNTs 在损伤部位可能比之前认为的更有好处；通过影响星形胶质细胞，它们可以更全面地恢复大脑的计算能力。
