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体外冲击波碎石术在儿科患者中有长期影响吗?

Are there long-term effects of extracorporeal shockwave lithotripsy in paediatric patients?

机构信息

Urology Department, Urology and Nephrology Centre, Mansoura University, Mansoura, Egypt.

出版信息

BJU Int. 2013 Apr;111(4):666-71. doi: 10.1111/j.1464-410X.2012.11420.x. Epub 2012 Aug 23.

Abstract

UNLABELLED

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Extracorporeal shockwave lithotripsy is effective for the treatment of paediatric renal stones with favourable short-term safety. Extracorporeal shockwave lithotripsy for treatment of paediatric renal stones is also safe for the kidney and the child on long-term follow-up.

OBJECTIVE

To evaluate the long-term effects of extracoporeal shockwave lithotripsy (SWL) for treatment of renal stones in paediatric patients.

PATIENTS AND METHODS

A database of paediatric patients who underwent SWL monotherapy for treatment of renal stones from September 1990 through to January 2009 was compiled. This study included only patients with follow-up for more than 2 years. The long-term effects of SWL were evaluated at the last follow-up with measurement of patients' arterial blood pressure, estimation of random blood sugar and urine analysis. The results of diastolic blood pressure were plotted against a standardized age reference curve. The treated kidney was examined by ultrasonography for measurement of renal length and detection of stones. The measured renal lengths were plotted against age-calculated normal renal lengths in healthy individuals.

RESULTS

The study included 70 patients (44 boys (63%) and 26 girls) with mean age at the time of SWL 6.5 ± 3.6 years (range 1-14). The mean follow-up period was 5.2 ± 3.6 years (range 2.1-17.5). The mean age at last follow-up was 11.7 ± 5.3 years (range 4.4-27.5). No patients developed hypertension or diabetes. Only one treated kidney was smaller than one standard deviation of the calculated length. The cause of this was obstruction by a stone in the pelvic ureter 3 years after SWL.

CONCLUSION

The long-term follow-up after SWL for treatment of renal stones in paediatric patients showed no effect on renal growth and no development of hypertension or diabetes.

摘要

目的

评估体外冲击波碎石术(SWL)治疗小儿肾结石的长期疗效。

患者和方法

我们编制了一份数据库,其中包括 1990 年 9 月至 2009 年 1 月期间接受 SWL 单一疗法治疗肾结石的小儿患者。本研究仅包括随访时间超过 2 年的患者。在最后一次随访时,通过测量患者的动脉血压、估计随机血糖和尿液分析来评估 SWL 的长期疗效。舒张压的结果与标准化年龄参考曲线进行比较。通过超声检查治疗后的肾脏,测量肾脏长度并检测结石。测量的肾脏长度与健康个体中年龄计算的正常肾脏长度进行比较。

结果

研究包括 70 例患者(44 名男孩(63%)和 26 名女孩),SWL 时的平均年龄为 6.5 ± 3.6 岁(范围 1-14 岁)。平均随访时间为 5.2 ± 3.6 年(范围 2.1-17.5 年)。最后一次随访时的平均年龄为 11.7 ± 5.3 岁(范围 4.4-27.5 岁)。没有患者发生高血压或糖尿病。只有一个治疗后的肾脏比计算长度的一个标准差小。其原因是 SWL 后 3 年骨盆输尿管内的结石引起梗阻。

结论

SWL 治疗小儿肾结石的长期随访结果显示,SWL 对肾脏生长没有影响,也没有发展为高血压或糖尿病。

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