Kimura M, Matsushima T, Nakamura J, Kobashi Y
Second Department of Medicine, Kawasaki Medical School, Okayama, Japan.
Antimicrob Agents Chemother. 1992 Dec;36(12):2774-7. doi: 10.1128/AAC.36.12.2774.
We investigated the transpleural penetration of lomefloxacin (LFLX) and ceftriaxone (CTRX). LFLX (200 mg) was administered orally to three patients with transudative fluid and four with exudative fluid, and 2 g of CTRX was administered by drip infusion to four patients with transudative fluid and three with exudative fluid. For both groups that received LFLX and CTRX, blood samples were drawn at time zero and 1, 2, and 6 h after drug administration. Thoracocentesis of each group was performed at 6 h after drug administration. The mean ratios of concentrations in pleural fluid/maximum concentrations in serum (P/S max) of LFLX were 66% in patients with transudative fluid and 69% in patients with exudative fluid. The mean ratios of P/S max of CTRX were 9.1% in patients with transudative fluid and 13.5% in patients with exudative fluid. The P/S max ratios for the penetration of LFLX were five to six times higher than those for CTRX. In addition, there was less differentiation in concentrations of LFLX in pleural fluid between the transudative and exudative effusions than there was in the concentrations of CTRX.
我们研究了洛美沙星（LFLX）和头孢曲松（CTRX）的经胸膜穿透情况。对3例漏出液患者和4例渗出液患者口服给予LFLX（200mg），对4例漏出液患者和3例渗出液患者静脉滴注给予2g CTRX。对于接受LFLX和CTRX的两组患者，在给药后0、1、2和6小时采集血样。每组在给药后6小时进行胸腔穿刺。LFLX在漏出液患者中的胸腔积液浓度/血清最大浓度（P/S max）平均比值为66%，在渗出液患者中为69%。CTRX在漏出液患者中的P/S max平均比值为9.1%，在渗出液患者中为13.5%。LFLX的经胸膜穿透P/S max比值比CTRX高5至6倍。此外，与CTRX浓度相比，漏出液和渗出液之间LFLX在胸腔积液中的浓度差异较小。
