Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:1007-12. doi: 10.1016/j.saa.2012.07.114. Epub 2012 Aug 4.
A novel, effective and simple surface-enhanced Raman scattering (SERS) nanosensor for selectively and sensitively detecting heavy metal ions in aqueous solution has been developed in the form of 2-mercaptoisonicotinic acid (2 MNA)-modified gold nanoparticles (AuNPs). Multiple heavy metal ions can be identified and quantified by using relative peak intensity ratios of selected vibrational bands in the SERS spectra of 2 MNA. Especially, concentration of Hg(2+) and Pb(2+) ions are determined by comparing the intensity ratios of the bands 1160/1230 cm(-1) for Hg(2+) and 861/815 cm(-1) (or 815/1392 cm(-1)) for Pb(2+), with detection limits of 3.4×10(-8) and 1.0×10(-7)M, respectively. 2 MNA-AuNPs sensors show a high selectivity for Hg(2+) without masking reagent, and they can also be highly selective for Pb(2+) when using sodium thiosulphate and l-cysteine as masking reagents. These results demonstrate that these 2 MNA-AuNPs nanosensors are promising candidates for in situ heavy metal ions detection and quantification, maybe even inside living cells.
一种新型的、有效的、简单的表面增强拉曼散射（SERS）纳米传感器，以 2-巯基异烟酸（2-MNA）修饰的金纳米粒子（AuNPs）的形式，用于选择性和灵敏地检测水溶液中的重金属离子。通过使用 SERS 光谱中 2-MNA 的选定振动带的相对峰强度比，可以识别和定量多种重金属离子。特别是，通过比较 Hg(2+)和 Pb(2+)离子的带 1160/1230 cm(-1)（或 815/1392 cm(-1))）的强度比，可以确定 Hg(2+)和 Pb(2+)离子的浓度，Hg(2+)和 Pb(2+)离子的检测限分别为 3.4×10(-8)和 1.0×10(-7)M。2-MNA-AuNPs 传感器在没有掩蔽试剂的情况下对 Hg(2+)具有高选择性，当使用硫代硫酸钠和 l-半胱氨酸作为掩蔽试剂时，它们对 Pb(2+)也具有高选择性。这些结果表明，这些 2-MNA-AuNPs 纳米传感器是用于原位重金属离子检测和定量的有前途的候选者，甚至可能在活细胞内。
