Department of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
Molecules. 2012 Aug 27;17(9):10258-66. doi: 10.3390/molecules170910258.
Camphor and borneol are wildly distributed in the essential oils of medicinal plants from various parts of the World. Our study has been carried out to evaluate the effect of these two bicyclic monoterpenes on rat thymocytes. Camphor and borneol at concentrations of 0.5 and 5 µg/mL did not induce significant toxicity on the immune system cells, while a significant increase of thymocyte viability was detected when cells were incubated with 50 µg/mL of camphor. A significant increase of cell viability was similarly detected when thymocytes were cultivated with borneol at concentrations of 0.5 and 5 µg/mL. The role of camphor and borneol in reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) disturbances in rat thymocytes as well as their potential mechanism(s) of action were also discussed.
樟脑和龙脑广泛分布于世界各地药用植物的精油中。我们的研究旨在评估这两种双环单萜类化合物对大鼠胸腺细胞的影响。樟脑和龙脑浓度为 0.5 和 5 µg/mL 时，对免疫系统细胞没有明显的毒性作用，而当细胞用 50 µg/mL 的樟脑孵育时，检测到胸腺细胞活力显著增加。当胸腺细胞用 0.5 和 5 µg/mL 的龙脑培养时，也同样检测到细胞活力的显著增加。本文还讨论了樟脑和龙脑在大鼠胸腺细胞中产生活性氧（ROS）和破坏线粒体膜电位（MMP）中的作用及其潜在的作用机制。
