加工微小核糖核酸病毒衣壳蛋白所需的蛋白酶存在于病毒复制酶基因中。
Protease required for processing picornaviral coat protein resides in the viral replicase gene.
作者信息
Palmenberg A C, Pallansch M A, Rueckert R R
出版信息
J Virol. 1979 Dec;32(3):770-8. doi: 10.1128/JVI.32.3.770-778.1979.
Abstract
Partial purification of the encephalomyocarditis protease synthesized in extracts from rabbit reticulocytes shows that the activity responsible for cleaving coat precursor protein cosediments with a previously unmapped virus-coded protein with an apparent molecular weight of 20,000. Tryptic analysis shows that this protein is derived from protein D, a virus-coded component of the encephalomyocarditis RNA polymerase.
摘要
对兔网织红细胞提取物中合成的脑心肌炎蛋白酶进行部分纯化，结果表明，负责切割衣壳前体蛋白的活性与一种先前未定位的病毒编码蛋白共沉降，该蛋白的表观分子量为20,000。胰蛋白酶分析表明，这种蛋白源自蛋白D，即脑心肌炎RNA聚合酶的一种病毒编码成分。
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