Department of Radiology, University Hospital Zurich, Zurich, Switzerland.
Skeletal Radiol. 2013 Mar;42(3):419-29. doi: 10.1007/s00256-012-1501-7. Epub 2012 Aug 29.
To determine the optimal intra-articular iodine concentration for C-arm flat-panel computed tomography (FPCT) arthrography using advanced joint phantoms and to evaluate its application in human cadaveric wrists and elbows. Multi-detector (MD) CT served as the standard of reference.
Joint phantoms and 10 human cadaveric wrist and elbow joints were scanned with C-arm FPCT (5-s, 8-s, and 20-s runs) and standard MDCT using different and optimal concentrations of iodinated contrast material. CT numbers of contrast material, tissue, and noise were measured and contrast-to-noise ratios (CNR) calculated for quantitative analysis. Image and depiction of cartilage, bone, and soft tissues were rated. Radiation doses were compared.
In FPCT, iodine concentrations positively correlated with CT numbers and noise of contrast material and with radiation dose (r = 0.713-0.996, p < 0.05 each). At an iodine concentration of 45 mg/ml, CNR of cartilage and soft tissues were highest for all FPCT acquisitions and higher than in MDCT. The 20-s FPCT run performed best for image quality and depiction of anatomical structures and was rated overall equal to MDCT (p = 0.857).
The optimal iodine concentration for C-arm FPCT arthrography in this study is 45 mg/ml, leading to superior CNR and image quality for an optimal FPCT protocol compared with standard MDCT arthrography in human cadaveric joints.
使用先进的关节模型，确定 C 臂平板 CT（FPCT）关节造影的最佳关节内碘浓度，并评估其在人类尸体腕关节和肘关节中的应用。多探测器（MD）CT 作为参考标准。
使用 C 臂 FPCT（5s、8s 和 20s 运行）和标准 MDCT 对关节模型和 10 个人体尸体腕关节和肘关节进行扫描，使用不同和最佳浓度的含碘对比剂。测量对比剂、组织和噪声的 CT 值，并计算对比噪声比（CNR）进行定量分析。评估图像和软骨、骨和软组织的显示。比较辐射剂量。
在 FPCT 中，碘浓度与对比剂的 CT 值和噪声以及辐射剂量呈正相关（r = 0.713-0.996，p < 0.05）。在碘浓度为 45mg/ml 时，所有 FPCT 采集的软骨和软组织的 CNR 最高，且高于 MDCT。20s 的 FPCT 运行在图像质量和解剖结构显示方面表现最佳，总体评分与 MDCT 相当（p = 0.857）。
在这项研究中，C 臂 FPCT 关节造影的最佳碘浓度为 45mg/ml，与标准 MDCT 关节造影相比，可在人体尸体关节中获得更高的 CNR 和图像质量。
