在亚马逊地区出现的巴西副球孢子菌：两例病例描述。
Occurrence of Paracoccidioides lutzii in the Amazon region: description of two cases.
机构信息
Evandro Chagas Institute, Bacteriology and Mycology Section, Mycology Laboratory, Ananindeua, Pará, Brazil.
出版信息
Am J Trop Med Hyg. 2012 Oct;87(4):710-4. doi: 10.4269/ajtmh.2012.12-0340. Epub 2012 Aug 27.
Abstract
Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin America, is known to be caused by at least four different phylogenetic lineages within the Paracoccidioides brasiliensis complex, including S1, PS2, PS3, and Pb01-like group. Herein, we describe two cases of PCM in patients native from the Amazon region. The disease was originally thought to have been caused by P. brasiliensis. Despite the severity of the cases, sera from the patients were negative in immunodiffusion tests using the standard exoantigen from P. brasiliensis B-339. However, a positive response was recorded with an autologous preparation of Paracoccidioides lutzii exoantigen. A phylogenetic approach based on the gp43 and ARF loci revealed high similarity between our clinical isolates and the Pb01-like group. The occurrence of PCM caused by P. lutzii in the Brazilian Amazon (Pará State) was thus proven. The incidence of PCM caused by P. lutzii may be underestimated in northern Brazil.
摘要
副球孢子菌病（PCM）是拉丁美洲最重要的人类系统性真菌病，已知由副球孢子菌复合体中的至少四个不同的系统发育谱系引起，包括 S1、PS2、PS3 和 Pb01 样群。在此，我们描述了来自亚马逊地区的两名 PCM 患者的病例。最初认为该疾病是由巴西副球孢子菌引起的。尽管病情严重，但患者的血清在使用巴西副球孢子菌 B-339 标准外抗原的免疫扩散试验中呈阴性。然而，与 Paracoccidioides lutzii 外抗原的自身制剂反应呈阳性。基于 gp43 和 ARF 基因座的系统发育方法显示，我们的临床分离株与 Pb01 样群高度相似。因此，证明了在巴西亚马逊地区（帕拉州）发生了由 P. lutzii 引起的 PCM。在巴西北部，由 P. lutzii 引起的 PCM 的发病率可能被低估。
相似文献
1
Occurrence of Paracoccidioides lutzii in the Amazon region: description of two cases.在亚马逊地区出现的巴西副球孢子菌：两例病例描述。
Am J Trop Med Hyg. 2012 Oct;87(4):710-4. doi: 10.4269/ajtmh.2012.12-0340. Epub 2012 Aug 27.
2
Paracoccidioides brasiliensis PS2: First Autochthonous Paracoccidioidomycosis Case Report in Rio de Janeiro, Brazil, and Literature Review.巴西副球孢子菌PS2：巴西里约热内卢首例本土副球孢子菌病病例报告及文献综述
Mycopathologia. 2016 Oct;181(9-10):701-8. doi: 10.1007/s11046-016-0015-6. Epub 2016 May 9.
3
Paracoccidioides lutzii sp. nov.: biological and clinical implications.新种巴西副球孢子菌：生物学和临床意义。
Med Mycol. 2014 Jan;52(1):19-28. doi: 10.3109/13693786.2013.794311.
4
Comparison of clinico-epidemiological and radiological features in paracoccidioidomycosis patients regarding serological classification using antigens from Paracoccidioides brasiliensis complex and Paracoccidioides lutzii.比较应用巴西副球孢子菌复合体和卢氏副球孢子菌抗原进行血清学分型的巴西副球孢子菌病患者的临床流行病学和影像学特征。
PLoS Negl Trop Dis. 2020 Aug 25;14(8):e0008485. doi: 10.1371/journal.pntd.0008485. eCollection 2020 Aug.
5
Ecology of Paracoccidioides brasiliensis, P. lutzii and related species: infection in armadillos, soil occurrence and mycological aspects.巴西副球孢子菌、卢氏副球孢子菌及相关菌种的生态学：犰狳感染、土壤中的存在情况及真菌学特征
Med Mycol. 2018 Nov 1;56(8):950-962. doi: 10.1093/mmy/myx142.
6
IgG reactivity profile to spp. antigens in people with asymptomatic Paracoccidioidomycosis.无症状粗球孢子菌病患者对 spp.抗原的 IgG 反应谱。
J Med Microbiol. 2021 Jan;70(1). doi: 10.1099/jmm.0.001279.
7
Molecular epidemiology of Paracoccidiodes spp. recovered from patients with paracoccidioidomycosis in a teaching hospital from Minas Gerais State of Brazil.巴西米纳斯吉拉斯州一教学医院从副球孢子菌病患者中分离的副球孢子菌的分子流行病学研究。
PLoS Negl Trop Dis. 2021 Nov 29;15(11):e0009956. doi: 10.1371/journal.pntd.0009956. eCollection 2021 Nov.
8
An update on the occurrence of Paracoccidioides species in the Midwest region, Brazil: Molecular epidemiology, clinical aspects and serological profile of patients from Mato Grosso do Sul State.巴西中西部地区副球孢子菌属的发生情况更新：南马托格罗索州患者的分子流行病学、临床特征和血清学概况
PLoS Negl Trop Dis. 2021 Apr 7;15(4):e0009317. doi: 10.1371/journal.pntd.0009317. eCollection 2021 Apr.
9
Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana.巴西副球孢子菌和美洲副球孢子菌共生种的临床特征和遗传背景。
PLoS Negl Trop Dis. 2019 Apr 15;13(4):e0007309. doi: 10.1371/journal.pntd.0007309. eCollection 2019 Apr.
10
Paracoccidioidomycosis cases by Paracoccidioides lutzii in southeastern Brazil.巴西东南部由巴西副球孢子菌引起的副球孢子菌病病例。
Braz J Microbiol. 2023 Sep;54(3):1761-1767. doi: 10.1007/s42770-023-01019-w. Epub 2023 Jun 8.
引用本文的文献
1
Insights into Magnetic Resonance Imaging Findings in Central Nervous System Paracoccidioidomycosis: A Comprehensive Review.中枢神经系统副球孢子菌病的磁共振成像表现洞察：全面综述
Res Rep Trop Med. 2023 Aug 3;14:87-98. doi: 10.2147/RRTM.S391633. eCollection 2023.
2
Molecular Phylogenetic Analysis of Species Complex Present in Paracoccidioidomycosis Patient Tissue Samples.副球孢子菌病患者组织样本中存在的物种复合体的分子系统发育分析
Microorganisms. 2023 Feb 23;11(3):562. doi: 10.3390/microorganisms11030562.
3
Paracoccidioides and Paracoccidioidomycosis in the 21st Century.二十一世纪的巴西副球孢子菌与巴西副球孢子菌病。
Mycopathologia. 2023 Apr;188(1-2):129-133. doi: 10.1007/s11046-022-00704-y. Epub 2023 Jan 12.
4
Paracoccidioidomycosis: Current Status and Future Trends.球孢子菌病：现状与未来趋势。
Clin Microbiol Rev. 2022 Dec 21;35(4):e0023321. doi: 10.1128/cmr.00233-21. Epub 2022 Sep 8.
5
Molecular epidemiology of Paracoccidiodes spp. recovered from patients with paracoccidioidomycosis in a teaching hospital from Minas Gerais State of Brazil.巴西米纳斯吉拉斯州一教学医院从副球孢子菌病患者中分离的副球孢子菌的分子流行病学研究。
PLoS Negl Trop Dis. 2021 Nov 29;15(11):e0009956. doi: 10.1371/journal.pntd.0009956. eCollection 2021 Nov.
6
Drk1, a Dimorphism Histidine Kinase, Contributes to Morphology, Virulence, and Stress Adaptation in .Drk1，一种双态组氨酸激酶，在……中对形态、毒力和应激适应起作用。 （原文句子不完整，缺少具体的生物名称等信息）
J Fungi (Basel). 2021 Oct 12;7(10):852. doi: 10.3390/jof7100852.
7
An update on the occurrence of Paracoccidioides species in the Midwest region, Brazil: Molecular epidemiology, clinical aspects and serological profile of patients from Mato Grosso do Sul State.巴西中西部地区副球孢子菌属的发生情况更新：南马托格罗索州患者的分子流行病学、临床特征和血清学概况
PLoS Negl Trop Dis. 2021 Apr 7;15(4):e0009317. doi: 10.1371/journal.pntd.0009317. eCollection 2021 Apr.
8
A New Duplex PCR-Assay for the Detection and Identification of Species.一种用于检测和鉴定物种的新型双重PCR检测方法。
J Fungi (Basel). 2021 Feb 26;7(3):169. doi: 10.3390/jof7030169.
9
Immunoproteomic Analysis Reveals Novel Candidate Antigens for the Diagnosis of Paracoccidioidomycosis Due to .免疫蛋白质组学分析揭示了新型候选抗原用于诊断由……引起的副球孢子菌病
J Fungi (Basel). 2020 Dec 11;6(4):357. doi: 10.3390/jof6040357.
10
Molecular Tools for Detection and Identification of Species: Current Status and Future Perspectives.用于物种检测和鉴定的分子工具：现状与未来展望
J Fungi (Basel). 2020 Nov 18;6(4):293. doi: 10.3390/jof6040293.
本文引用的文献
1
CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.系统发育树的置信区间：一种使用自展法的方法。
Evolution. 1985 Jul;39(4):783-791. doi: 10.1111/j.1558-5646.1985.tb00420.x.
2
Paracoccidioidomycosis epidemiological features of a 1,000-cases series from a hyperendemic area on the southeast of Brazil.巴西东南部高度流行地区 1000 例病例系列的球孢子菌病流行病学特征。
Am J Trop Med Hyg. 2011 Sep;85(3):546-50. doi: 10.4269/ajtmh.2011.11-0084.
3
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.MEGA5：用于最大似然法、进化距离法和最大简约法的分子进化遗传学分析。
Mol Biol Evol. 2011 Oct;28(10):2731-9. doi: 10.1093/molbev/msr121. Epub 2011 May 4.
4
Development and evaluation of a latex agglutination test for the serodiagnosis of paracoccidioidomycosis.用于副球孢子菌病血清诊断的乳胶凝集试验的开发与评估
Clin Vaccine Immunol. 2011 Apr;18(4):604-8. doi: 10.1128/CVI.00130-10. Epub 2011 Feb 16.
5
Serological diagnosis of paracoccidioidomycosis in HIV-coinfected patients.HIV 合并感染患者的副球孢子菌病血清学诊断。
Mem Inst Oswaldo Cruz. 2010 Nov;105(7):904-7. doi: 10.1590/s0074-02762010000700011.
6
Is the geographical origin of a Paracoccidioides brasiliensis isolate important for antigen production for regional diagnosis of paracoccidioidomycosis?巴西副球孢子菌分离株的地理来源对于副球孢子菌病的区域诊断抗原生产是否重要？
Mycoses. 2010 Mar 1;53(2):176-80. doi: 10.1111/j.1439-0507.2008.01687.x. Epub 2009 Apr 23.
7
Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus.系统发育分析揭示了副球孢子菌属中高度的物种形成。
Mol Phylogenet Evol. 2009 Aug;52(2):273-83. doi: 10.1016/j.ympev.2009.04.005. Epub 2009 Apr 17.
8
An atypical Paracoccidioides brasiliensis clinical isolate based on multiple gene analysis.基于多位点基因分析的一株非典型巴西副球孢子菌临床分离株。
Med Mycol. 2010 Feb;48(1):64-72. doi: 10.3109/13693780902718065.
9
Phylogenetic analysis of PRP8 intein in Paracoccidioides brasiliensis species complex.巴西副球孢子菌复合种中PRP8内含肽的系统发育分析。
Fungal Genet Biol. 2008 Sep;45(9):1284-91. doi: 10.1016/j.fgb.2008.07.003. Epub 2008 Jul 11.
10
New Paracoccidioides brasiliensis isolate reveals unexpected genomic variability in this human pathogen.新型巴西副球孢子菌分离株揭示了这种人类病原体意想不到的基因组变异性。
Fungal Genet Biol. 2008 May;45(5):605-12. doi: 10.1016/j.fgb.2008.02.002. Epub 2008 Feb 21.
Zotero 插件