Miyauchi T, Marouka M, Nagayama T, Wakatsuki S
Department of Pathology, Chiba Cancer Center Reserach Institute.
Nihon Hinyokika Gakkai Zasshi. 1990 Dec;81(12):1908-11. doi: 10.5980/jpnjurol1989.81.1908.
Two cases (spouses) of carcinoma of the ureter possibly induced by long-term use of analgesic were presented. Case 1: A 66-year-old female with hematuria was diagnosed as a carcinoma of the ureter in January, 1985 and underwent resection of the left kidney and the ureter with partial resection of the urinary bladder. In December, 1988 she died due to recurrent cancer. Case 2: A 70-year-old male (a husband of case 1 patient) with hematuria was diagnosed as a carcinoma of the ureter in August, 1987 and underwent resection of the kidney and the ureter of the left side. In October, 1988 he died due to recurrent cancer. These two patients had used routinely phenacetin because of persistent headache for about 20 and 15 years, respectively and the presumed total dose was amounted to 4 and 2.5 kg, respectively.
本文报告了两例（夫妻）可能因长期使用镇痛药诱发的输尿管癌病例。病例1：一名66岁女性，因血尿于1985年1月被诊断为输尿管癌，并接受了左肾、输尿管及部分膀胱切除术。1988年12月，她因癌症复发去世。病例2：一名70岁男性（病例1患者的丈夫），因血尿于1987年8月被诊断为输尿管癌，并接受了左侧肾脏和输尿管切除术。1988年10月，他因癌症复发去世。这两名患者分别因持续性头痛常规服用非那西丁约20年和15年，推测总剂量分别达4千克和2.5千克。
