β 细胞动力学的神经功能成像。
Neurofunctional imaging of β-cell dynamics.
机构信息
Division of Endocrinology, Department of Medicine, The Naomi Berrie Diabetes Center and Columbia University College of Physicians and Surgeons, New York, NY, USA.
出版信息
Diabetes Obes Metab. 2012 Oct;14 Suppl 3(0 3):91-100. doi: 10.1111/j.1463-1326.2012.01651.x.
Abstract
Here, we outline how islet cells use autocrine and paracrine 'circuits' of classical neurotransmitters and their corresponding receptors and transporters to communicate with vicinal β-cells to regulate glucose-stimulated insulin secretion. Many of these same circuits operate in the central nervous system and can be visualized by molecular imaging. We discuss how these techniques might be applied to measuring the dynamics of β-cell function in real time.
摘要
在这里，我们概述了胰岛细胞如何利用经典神经递质及其相应的受体和转运体的自分泌和旁分泌“回路”与邻近的β细胞进行通讯，以调节葡萄糖刺激的胰岛素分泌。许多相同的回路在中枢神经系统中起作用，可以通过分子成像来观察。我们讨论了这些技术如何应用于实时测量β细胞功能的动态。
相似文献
1
Neurofunctional imaging of β-cell dynamics.β 细胞动力学的神经功能成像。
Diabetes Obes Metab. 2012 Oct;14 Suppl 3(0 3):91-100. doi: 10.1111/j.1463-1326.2012.01651.x.
2
[Behavior of pancreatic beta-cells in type I and II diabetes: clinical implications?].
Rev Med Suisse Romande. 1995 Sep;115(9):627-34.
3
INS VNTR class genotype and the function of isolated human islets.胰岛素可变数目串联重复序列（INS VNTR）类别基因型与分离的人胰岛功能
Nutr Metab Cardiovasc Dis. 2011 Mar;21(3):e9-11. doi: 10.1016/j.numecd.2010.10.005. Epub 2010 Dec 30.
4
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats.垂体腺苷酸环化酶激活多肽（PACAP）是一种胰岛物质，在大鼠体内作为葡萄糖诱导胰岛素分泌的胰岛内放大器。
J Physiol. 1997 Dec 1;505 ( Pt 2)(Pt 2):319-28. doi: 10.1111/j.1469-7793.1997.319bb.x.
5
Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes.在β细胞中过表达胰岛素样生长因子-II的转基因小鼠会患2型糖尿病。
J Clin Invest. 2000 Mar;105(6):731-40. doi: 10.1172/JCI5656.
6
Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets.胰岛淀粉样多肽抑制分离的大鼠胰岛的葡萄糖刺激的胰岛素分泌。
Biochem Biophys Res Commun. 1989 Apr 28;160(2):961-7. doi: 10.1016/0006-291x(89)92529-1.
7
Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats.胰岛素分泌、β细胞质量和胰岛血流灌注的早期缺陷先于 BioBreeding 大鼠自身免疫 1 型糖尿病的发病。
Diabetologia. 2018 Apr;61(4):896-905. doi: 10.1007/s00125-017-4512-z. Epub 2017 Dec 6.
8
Role of islet peptides in beta cell regulation and type 2 diabetes therapy.胰岛肽在β细胞调节和 2 型糖尿病治疗中的作用。
Peptides. 2018 Feb;100:212-218. doi: 10.1016/j.peptides.2017.11.014.
9
Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.金属硫蛋白 1 负调控葡萄糖刺激的胰岛素分泌，并在小鼠和人类的β细胞代偿和衰竭情况下有差异表达。
Diabetologia. 2019 Dec;62(12):2273-2286. doi: 10.1007/s00125-019-05008-3. Epub 2019 Oct 17.
10
Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes.在肥胖型沙鼠2型糖尿病模型中，与胰腺十二指肠同源盒-1（PDX-1）缺乏相关的葡萄糖调节胰岛素基因表达缺陷。
Diabetes. 2001 Feb;50 Suppl 1:S138-9. doi: 10.2337/diabetes.50.2007.s138.
引用本文的文献
1
Molecular imaging of β-cells: diabetes and beyond.β细胞的分子影像学：糖尿病及其他。
Adv Drug Deliv Rev. 2019 Jan 15;139:16-31. doi: 10.1016/j.addr.2018.06.022. Epub 2018 Jul 3.
2
Futility of attempts to detect and quantify beta cells by PET imaging in the pancreas: why it is time to abandon the approach.通过 PET 成像检测和定量胰腺β细胞的尝试是徒劳的：是时候放弃这种方法了。
Diabetologia. 2018 Dec;61(12):2512-2515. doi: 10.1007/s00125-018-4676-1. Epub 2018 Jun 29.
3
Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells.研究资源：一种用于检测分泌血清素和组胺的肠内分泌细胞的嗜铬粒蛋白A报告基因。
Mol Endocrinol. 2015 Nov;29(11):1658-71. doi: 10.1210/me.2015-1106. Epub 2015 Sep 9.
4
Imaging pancreas in healthy and diabetic rodent model using [18F]fallypride positron emission tomography/computed tomography.使用[18F]氟哌利多正电子发射断层扫描/计算机断层扫描对健康和糖尿病啮齿动物模型中的胰腺进行成像。
Diabetes Technol Ther. 2014 Oct;16(10):640-3. doi: 10.1089/dia.2014.0041. Epub 2014 May 14.
本文引用的文献
1
In vivo imaging of endogenous pancreatic β-cell mass in healthy and type 1 diabetic subjects using 18F-fluoropropyl-dihydrotetrabenazine and PET.使用 18F-氟丙基-二氢四苯并嗪和正电子发射断层扫描（PET）对健康和 1 型糖尿病患者内源性胰腺β细胞质量进行体内成像。
J Nucl Med. 2012 Jun;53(6):908-16. doi: 10.2967/jnumed.111.100545. Epub 2012 May 9.
2
Bariatric surgery versus intensive medical therapy in obese patients with diabetes.肥胖伴糖尿病患者的减肥手术与强化内科治疗的比较。
N Engl J Med. 2012 Apr 26;366(17):1567-76. doi: 10.1056/NEJMoa1200225. Epub 2012 Mar 26.
3
Bariatric surgery versus conventional medical therapy for type 2 diabetes.减重手术与常规药物疗法治疗 2 型糖尿病的疗效比较。
N Engl J Med. 2012 Apr 26;366(17):1577-85. doi: 10.1056/NEJMoa1200111. Epub 2012 Mar 26.
4
Diabetes mellitus and the β cell: the last ten years.糖尿病与β细胞：近十年的研究进展。
Cell. 2012 Mar 16;148(6):1160-71. doi: 10.1016/j.cell.2012.02.010.
5
18F-DOPA PET/CT biodistribution consideration in 107 consecutive patients with neuroendocrine tumours.107例连续神经内分泌肿瘤患者的18F-多巴PET/CT生物分布情况
Nucl Med Commun. 2012 Feb;33(2):179-84. doi: 10.1097/MNM.0b013e32834e0974.
6
Convergence of the insulin and serotonin programs in the pancreatic β-cell.胰岛素和血清素程序在胰腺 β 细胞中的收敛。
Diabetes. 2011 Dec;60(12):3208-16. doi: 10.2337/db10-1192. Epub 2011 Oct 19.
7
In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions.从对二氮嗪有抗性的先天性高胰岛素血症婴儿的胰腺组织中体外胰岛素分泌与模型预测结果不同。
J Clin Invest. 2011 Oct;121(10):3932-42. doi: 10.1172/JCI58400. Epub 2011 Sep 26.
8
The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells.胰岛素分泌的双重葡萄糖控制涉及β细胞中触发和放大途径。
Diabetes Res Clin Pract. 2011 Aug;93 Suppl 1:S27-31. doi: 10.1016/S0168-8227(11)70010-9.
9
SLC6 neurotransmitter transporters: structure, function, and regulation.SLC6 神经递质转运体：结构、功能和调节。
Pharmacol Rev. 2011 Sep;63(3):585-640. doi: 10.1124/pr.108.000869. Epub 2011 Jul 13.
10
Innervation patterns of autonomic axons in the human endocrine pancreas.人类内分泌胰腺自主神经轴突的神经支配模式。
Cell Metab. 2011 Jul 6;14(1):45-54. doi: 10.1016/j.cmet.2011.05.008.
Zotero 插件