O'Hagan Bj, Pasloske K, McKinnon C, Perkins Nr, Whittem T
Jurox Pty Ltd, Rutherford, New South Wales, Australia.
Aust Vet J. 2012 Sep;90(9):346-50. doi: 10.1111/j.1751-0813.2012.00974.x. Epub 2012 Jul 24.
To assess the efficacy of alfaxalone as an anaesthetic induction agent for dogs aged less than 12 weeks.
The study group comprised 25 juvenile dogs aged less than 12 weeks that were presented for surgical desexing. Dogs were aged by dentition, examined and weighed prior to premedication with acepromazine, atropine and morphine. At 20-30 min after premedication, animals were anaesthetised with intravenous alfaxalone administered to effect, using a target maximum expected dose of 2 mg/kg. Dogs were intubated and anaesthesia was maintained with isoflurane in oxygen administered with a non-rebreathing system. Subjective measures of anaesthetic quality and vital signs were recorded from enrollment to recovery. Descriptive and comparative statistics were used to analyse and present collected data.
The mean (± SD) dose of alfaxalone for induction was 1.7 (± 0.3) mg/kg body weight. Subjective measures of anaesthetic quality indicated acceptable induction, maintenance and recovery standards. Measured cardiovascular and respiratory parameters were well maintained.
Alfaxalone in 2-hydroxypropyl-beta-cyclodextrin (Alfaxan®) is a suitable injectable anaesthetic induction agent for dogs aged less than 12 weeks requiring anaesthesia.
评估阿法沙龙作为12周龄以下犬类麻醉诱导剂的疗效。
研究组包括25只12周龄以下的幼犬，这些幼犬因手术去势前来就诊。在使用乙酰丙嗪、阿托品和吗啡进行术前用药前，根据牙齿情况对犬只进行年龄判断、检查并称重。术前用药后20 - 30分钟，用静脉注射阿法沙龙进行麻醉，直至起效，目标最大预期剂量为2mg/kg。对犬只进行插管，并使用无重复吸入系统，通过在氧气中使用异氟醚维持麻醉。记录从入组到恢复期间麻醉质量和生命体征的主观指标。使用描述性和比较性统计方法对收集到的数据进行分析和呈现。
阿法沙龙诱导的平均（±标准差）剂量为1.7（±0.3）mg/kg体重。麻醉质量的主观指标表明诱导、维持和恢复标准均可接受。所测量的心血管和呼吸参数维持良好。
2-羟丙基-β-环糊精中的阿法沙龙（Alfaxan®）是一种适用于需要麻醉的12周龄以下犬类的可注射麻醉诱导剂。
