Institute of Social and Family Medicine, School of Public Health, Zhejiang University , Hangzhou , China.
Acta Oncol. 2012 Sep;51(7):915-21. doi: 10.3109/0284186X.2012.708105. Epub 2012 Aug 29.
Population-based studies on cervical cancer providing survival estimates by age, histology, and stage have been sparse. We aimed to derive most up-to-date and detailed survival estimates for cervical cancer patients in Germany.
We used a pooled German national dataset including data from 11 cancer registries covering a population of 33 million people. Included were 15 685 patients diagnosed with cervical cancer from 1997 to 2006. Period analysis was performed to calculate the five-year relative survival (RS) 2002-2006. Trends in survival between 2002 and 2006 were examined using model-based period analysis. Age-adjustment was done using five age groups (15-44, 45-54, 55-64, 65-74, and 75 + years).
Overall, age-adjusted five-year relative survival in 2002-2006 was 64.7%. A strong age gradient was observed, with five-year RS decreasing from 81.7% in age group 15-49 years to 46.3% in age group 70 + years. Prognosis furthermore strongly varied by stage, with age-adjusted five-year RS reaching 84.6% for localized, 48.2% for regional, and 17.9% for distant stage. From 2002 to 2006, a significant improvement (4.7 percent units) in overall age-adjusted five-year RS was seen. The improvement was most pronounced for age groups 55-64 years (from 54.2 to 65.6%) and 65-74 years (from 50.0 to 58.1%).
In this first comprehensive population-based study from Germany, prognosis of cervical cancer strongly varied by age and stage. Prognosis continued to improve, in particular in age range 55-74 years, in the five-year period assessed.
基于人群的宫颈癌生存研究，按年龄、组织学和分期提供生存估计数据较为少见。本研究旨在为德国宫颈癌患者提供最新和最详细的生存估计数据。
我们使用了一个汇集的德国国家数据集，该数据集包含了来自 11 个癌症登记处的数据，覆盖了 3300 万人。该研究纳入了 1997 年至 2006 年间诊断为宫颈癌的 15685 名患者。通过对 2002-2006 年的时期进行分析，计算了五年相对生存率（RS）。使用基于模型的时期分析来检查 2002 年至 2006 年期间的生存趋势。使用五个年龄组（15-44、45-54、55-64、65-74 和 75+岁）进行年龄调整。
总体而言，2002-2006 年的年龄调整后五年相对生存率为 64.7%。观察到明显的年龄梯度，5 年 RS 从 15-49 岁年龄组的 81.7%下降到 70+岁年龄组的 46.3%。预后还因分期而异，局限性病变的年龄调整后五年 RS 为 84.6%，区域性病变为 48.2%，远处转移病变为 17.9%。从 2002 年到 2006 年，总体年龄调整后五年 RS 显著提高（4.7 个百分点）。55-64 岁年龄组（从 54.2%提高到 65.6%）和 65-74 岁年龄组（从 50.0%提高到 58.1%）的改善最为显著。
在这项来自德国的首次全面人群研究中，宫颈癌的预后因年龄和分期而异。在评估的五年期间，预后继续改善，特别是在 55-74 岁年龄组。
