Hayasaka Eye Clinic, Sakura, Tochigi, Japan.
Am J Chin Med. 2012;40(5):887-904. doi: 10.1142/S0192415X12500668.
Herbal medicines have been used clinically in Eastern Asia, and traditional Japanese herbal (Kampo) formulas are approved as ethical drugs. The Kampo formulas are mixtures of the crude extracts of several herbs, each of which contains multiple components. Numerous investigators have reported that some herbal medicines are efficacious for treating several human diseases. We reviewed the literature on traditional herbal medicines and treatment of ocular diseases. Oral Orengedoku-to and Kakkon-to inhibit postoperative uveitis in humans. Oral Goshajinki-gan improved ocular surface disorders in patients with type 1 diabetes mellitus. Oral Hachimijio-gan increased retinal blood flow. Keishi-bukuryo-gan Sho might be associated with vitreoretinopathy in patients with type 2 diabetes mellitus. Oral Hachimijio-gan and Goshajinki-gan delayed lens opacification in rats and mice. Oral Sairei-to, Orengedoku-to, Senkanmeimoku-to, Scutellariae radix extract, Gardeniae fructus extract, topical Liguisticum wallichii rhizoma extract, and intravenous injection of tetramethylpyrazine, baicalin, baicalein, wogonin, and crocetin inhibited some forms of experimental uveitis in rabbits. Topical glycyrrhizinate improved allergic conjunctivitis in humans and rats. Oral crocetin improved eyestrain in humans. Oral berberine diminished experimental uveitis in rats. Baicalein, wogonin, berberine, and berberrubine inhibited in vitro expression of several cytokines in cultured retinal pigment epithelial cells. Some Kampo formulas are efficacious for treating several ocular diseases in humans and animals. Some herbal extracts and their components inhibit some forms of experimental uveitis.
草药在东亚临床上得到应用，传统的日本草药（汉方药）方剂被批准为合法药物。汉方药方剂是由几种草药的粗提取物混合而成，每种草药都含有多种成分。许多研究人员报告说，一些草药对治疗几种人类疾病有效。我们综述了传统草药和眼部疾病治疗的文献。口服黄连解毒汤和加味逍遥散可抑制人类术后葡萄膜炎。口服归脾丸可改善 1 型糖尿病患者的眼表疾病。口服八味地黄丸可增加视网膜血流量。可能与 2 型糖尿病患者的玻璃体液视网膜病变有关。口服八味地黄丸和归脾丸可延缓大鼠和小鼠晶状体混浊。口服柴苓汤、黄连解毒汤、四物消风散、黄芩提取物、栀子提取物、甘草酸局部给药、川芎嗪静脉注射可抑制兔实验性葡萄膜炎的某些类型。局部给予甘草酸可改善人类和大鼠的过敏性结膜炎。口服藏红花可改善人类视疲劳。口服小檗碱可减轻大鼠实验性葡萄膜炎。白杨素、汉黄芩素、小檗碱、小檗红碱可抑制体外培养的视网膜色素上皮细胞中几种细胞因子的表达。一些汉方药方剂对人类和动物的几种眼部疾病有效。一些草药提取物及其成分可抑制某些类型的实验性葡萄膜炎。
