Comprehensive Education Center for Community Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba Ward, Sendai City 980-8575, Japan ; Department of Education and Support for Community Medicine, Tohoku University Hospital, 1-1 Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan.
Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan.
Evid Based Complement Alternat Med. 2014;2014:586857. doi: 10.1155/2014/586857. Epub 2014 Apr 24.
The aim of this study was to examine the effects of oral administration of kampo medical formulas on ocular blood flow (OBF). A crossover protocol was used to randomly administer five grams of yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan to 13 healthy blinded subjects (mean age: 37.3 ± 12.3 years). The mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, was measured at the optic nerve head before and 30 minutes after administration. Blood pressure (BP) and intraocular pressure (IOP) were also recorded. No significant changes were observed in mean BP or IOP after the administration of any of the kampo medical formulas. There was a significant increase in OBF 30 minutes after administration of TSS (100% to 103.6 ± 6.9%, P < 0.01). Next, TSS was administered to 19 healthy subjects (mean age: 32.0 ± 11.0 years) and OBF was measured before and 15, 30, 45, and 60 minutes after administration. Plain water was used as a control. OBF increased significantly after TSS administration compared to control (P < 0.01) and also increased from 30 to 60 minutes after administration compared to baseline (P < 0.05). These results suggest that TSS can increase OBF without affecting BP or IOP in healthy subjects.
本研究旨在考察口服汉方药对眼血流（OBF）的影响。采用交叉方案随机给予 13 名健康盲人受试者（平均年龄：37.3 ± 12.3 岁）5 克的和汉生药 yokukansan、tokishakuyakusan（TSS）、keishibukuryogan 或 hachimijiogan。使用激光散斑血流图测量视神经头部的平均模糊率，这是一种定量 OBF 指数，在给药前和给药后 30 分钟进行测量。还记录了血压（BP）和眼内压（IOP）。在给予任何汉方药后，平均 BP 或 IOP 均无明显变化。给予 TSS 后 30 分钟 OBF 显著增加（100%至 103.6 ± 6.9%，P < 0.01）。接下来，给予 19 名健康受试者（平均年龄：32.0 ± 11.0 岁）TSS，并在给药前和给药后 15、30、45 和 60 分钟测量 OBF。白开水用作对照。与对照相比，TSS 给药后 OBF 显著增加（P < 0.01），与基线相比，给药后 30 至 60 分钟 OBF 也增加（P < 0.05）。这些结果表明，TSS 可增加 OBF，而不影响健康受试者的 BP 或 IOP。
