肠圣饮醇提物对骨髓来源肥大细胞介导的过敏反应的抗炎作用。
The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells.
机构信息
College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University, Jeonbuk 570-749, Republic of Korea.
出版信息
Chin J Integr Med. 2013 May;19(5):380-6. doi: 10.1007/s11655-013-1448-0. Epub 2013 Mar 15.
OBJECTIVE
Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction () and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms.
METHODS
In this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included interleukin-6 (IL-6), prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and β-hexosaminidase (β-hex).
RESULTS
Our data revealed that CITE inhibited the production of IL-6, PGD2, LTC4, and β-hex induced by PMA plus A23187 (P<0.05).
CONCLUSION
These findings indicate that CITE has the potential for use in the treatment of allergy.
目的
清暑益气汤（CIT，韩国），也被称为清气益气汤（）和十全大补汤（日本），作为治疗心血管疾病的有效传统草药组合而闻名。本研究旨在研究其对骨髓来源的肥大细胞（BMMC）介导的过敏和炎症机制的影响。
方法
在这项研究中，评估了清暑益气汤乙醇提取物（CITE）的生物学效应，重点研究其对佛波醇 12-肉豆蔻酸 13-乙酸酯（PMA）加钙离子载体 A23187（A23187）刺激的 BMMC 产生过敏介质的影响。这些过敏介质包括白细胞介素 6（IL-6）、前列腺素 D2（PGD2）、白三烯 C4（LTC4）和β-己糖胺酶（β-hex）。
结果
我们的数据显示，CITE 抑制了 PMA 加 A23187 诱导的 IL-6、PGD2、LTC4 和β-hex 的产生（P<0.05）。
结论
这些发现表明 CITE 具有治疗过敏的潜力。
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