Dhakhwa R, Acharya I L, Shrestha H G, Joshi D M, Lama S, Lakhey M
Department of Pathology, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal.
J Nepal Health Res Counc. 2012 Jan;10(1):57-60.
Gastritis has a broad histopathologic and topographical spectrum and leads to different patterns of disease. The introduction of the Sydney system made it possible to grade histological parameters, identify topographic distribution and provide etiological information which would help to generate reproducible and clincally useful diagnoses. The aim of this study was to determine the prevalence of Helicobacter pylori in non-ulcer dyspepsia, duodenal ulcer and gastric ulcer; and to assess the histopathologic features associated with chronic gastritis.
Gastric antral biopsy specimens from 200 patients were examined for the prevalence of H. pylori, and were classified and graded histologically.
The overall colonization rate of H. pylori was 44%. The colonization rates were 85%, 67% and 41% in patients with duodenal ulcer, gastric ulcer and non-ulcer dyspepsia respectively. There was not much difference between the degree of atrophy and intestinal metaplasia in H. pylori positive and negative cases.
Helicobacter gastritis is the commonest type of gastritis present in patients presenting with dyspeptic symptoms. It is more common in patients presenting with duodenal ulcer. Adequate sampling is a must for accurate diagnosis of H. pylori colonization.
胃炎具有广泛的组织病理学和解剖学谱，并导致不同的疾病模式。悉尼系统的引入使得对组织学参数进行分级、确定解剖学分布并提供病因信息成为可能，这有助于做出可重复且临床有用的诊断。本研究的目的是确定幽门螺杆菌在非溃疡性消化不良、十二指肠溃疡和胃溃疡中的患病率；并评估与慢性胃炎相关的组织病理学特征。
对200例患者的胃窦活检标本进行幽门螺杆菌患病率检查，并进行组织学分类和分级。
幽门螺杆菌的总体定植率为44%。十二指肠溃疡、胃溃疡和非溃疡性消化不良患者的定植率分别为85%、67%和41%。幽门螺杆菌阳性和阴性病例的萎缩程度和肠化生程度差异不大。
幽门螺杆菌胃炎是有消化不良症状患者中最常见的胃炎类型。在十二指肠溃疡患者中更常见。为准确诊断幽门螺杆菌定植，必须进行充分采样。
